GUT2 glycerol-3-phosphate dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GUT2
Official Full Name: glycerol-3-phosphate dehydrogenase
Primary source: SGD:S000001417
Locus tag: YIL155C
See related: AllianceGenome:SGD:S000001417; FungiDB:YIL155C; VEuPathDB:YIL155C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glycerol-3-phosphate dehydrogenase (quinone) activity. Involved in NADH oxidation and glycerol metabolic process. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GUT2 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (51759..53708, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PC depletion was found to reduce growth on glycerol and to increase glycerol excretion, both indicating that PC is needed for optimal Gut2 functioning in vivo
Title: Phosphatidylcholine is essential for efficient functioning of the mitochondrial glycerol-3-phosphate dehydrogenase Gut2 in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glycerol-3-phosphate dehydrogenase (quinone) activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-3-phosphate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in organophosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: glycerol-3-phosphate dehydrogenase

NP_012111.1

EC 1.1.5.3

Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

51759..53708 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179503.1 → NP_012111.1 TPA: glycerol-3-phosphate dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012111.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVD2, E9P8Y2, P32191

UniProtKB/TrEMBL

A6ZVC1, B3LU02, B5VKF7, C7GUS1, G2WFZ7, N1P1P0

Conserved Domains (1) summary

COG0578
Location:84 → 649

GlpA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]