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    NEDD4 NEDD4 E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 4734, updated on 27-Nov-2024

    Summary

    Official Symbol
    NEDD4provided by HGNC
    Official Full Name
    NEDD4 E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:7727
    See related
    Ensembl:ENSG00000069869 MIM:602278; AllianceGenome:HGNC:7727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPF1; NEDD4-1
    Summary
    This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 6.4), liver (RPKM 5.9) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NEDD4 in Genome Data Viewer
    Location:
    15q21.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (55826917..55993612, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (53630346..53797054, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56119115..56285810, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 1 Neighboring gene uncharacterized LOC124903497 Neighboring gene NANOG hESC enhancer GRCh37_chr15:55953352-55954256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:55957303-55957803 Neighboring gene protogenin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9449 Neighboring gene NANOG hESC enhancer GRCh37_chr15:56028112-56028613 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:56034229-56035192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:56036083-56036584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:56036585-56037084 Neighboring gene NEDD4 intron nontranscribed DNase I hypersensitive site-defined enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40173 Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:56250068-56250245 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:56285058-56285840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6460 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:56286819-56287016 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:56300574-56300741 Neighboring gene CNOT6L pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 568, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
    EBI GWAS Catalog
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
    Envelope surface glycoprotein gp160, precursor env Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
    Nef nef HIV-1 Nef co-localizes with CXCR4, AIP4, NEDD4, CD63/LAMP-1-positive vesicles, and HRS/VPS27-positive ESCRT-0 structures in HeLa cells PubMed
    nef HIV-1 Nef co-localizes with E3 ubiquitin ligases AIP4 and NEDD4. HIV-1 Nef induced degradation of GNAI2 involves AIP4 and NEDD4 through recruitment of AIP4 and NEDD4 by Nef PubMed
    Pr55(Gag) gag Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
    gag Overexpression of Nedd4-1 rescues the HIV-1 PTAP- mutant budding defects and the ubiquitin ligase activity of Nedd4-1 and the LYPXnL motif of Gag/p6 are required for the Nedd4-1-mediated rescue PubMed
    gag Nedd4 is one possible ubiquitin ligase implicated to interact with the L domain of HIV-1 p6-Gag resulting in monoubiquitination of p6 PubMed
    gag Nedd4-1 facilitation of HIV-1 PTAP(-) release requires basic residues in Gag/NC PubMed
    gag The leucine residues (211LYPL214 motif) within the C2 domain of Nedd4-1 mediate binding to Gag and play a critical role in Nedd4-1-mediated rescue of HIV-1 PTAP(-) PubMed
    gag Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells PubMed
    gag The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 PubMed
    Vif vif HIV-1 Vif, through amino acids 20-128, binds to the WW domains of hNedd4 and AIP4, two HECT E3 ubiquitin ligases PubMed
    capsid gag Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells. NEDD4-induced upregulation of p24 levels is mediated by the C2 domain (residues 20-151) of NEDD4 PubMed
    p6 gag Overexpression of Nedd4-1 rescues the HIV-1 PTAP- mutant budding defects and the ubiquitin ligase activity of Nedd4-1 and the LYPXnL motif of Gag/p6 are required for the Nedd4-1-mediated rescue PubMed
    gag Nedd4 is one possible ubiquitin ligase implicated to interact with the L domain of HIV-1 p6-Gag resulting in monoubiquitination of p6 PubMed
    gag Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells PubMed
    gag The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0093, MGC176705

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-2 adrenergic receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphoserine residue binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphothreonine residue binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables proline-rich region binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in formation of structure involved in a symbiotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_positive_effect innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lysosomal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in nuclear receptor-mediated glucocorticoid signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in progesterone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein targeting to lysosome IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to calcium ion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of viral budding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apicolateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NEDD4
    Names
    HECT-type E3 ubiquitin transferase NEDD4
    cell proliferation-inducing gene 53 protein
    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    receptor-potentiating factor 1
    NP_001271267.1
    NP_001271268.1
    NP_001271269.1
    NP_001316141.1
    NP_006145.2
    NP_940682.2
    XP_011519926.1
    XP_011519927.1
    XP_011519928.1
    XP_054233998.1
    XP_054233999.1
    XP_054234000.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051072.1 RefSeqGene

      Range
      5135..171825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001284338.2NP_001271267.1  E3 ubiquitin-protein ligase NEDD4 isoform 3

      See identical proteins and their annotated locations for NP_001271267.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains three alternate in-frame exons, compared to variant 2. The encoded isoform (3) is longer than isoform 2.
      Source sequence(s)
      AC009997, AC039057
      Consensus CDS
      CCDS61644.1
      UniProtKB/Swiss-Prot
      A1KY35, A6ND72, A7MD29, B4E2R7, B7ZM59, B7ZM60, B9EGN5, D6RF89, P46934
      Related
      ENSP00000424827.1, ENST00000508342.5
      Conserved Domains (4) summary
      smart00456
      Location:893925
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9861315
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:769798
      WW; WW domain
      cl14603
      Location:517570
      C2; C2 domain
    2. NM_001284339.1NP_001271268.1  E3 ubiquitin-protein ligase NEDD4 isoform 4

      See identical proteins and their annotated locations for NP_001271268.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (4) is longer than isoform 2.
      Source sequence(s)
      AC009997, AL832063, BC136605, BC144285
      Consensus CDS
      CCDS61643.1
      UniProtKB/Swiss-Prot
      P46934
      Related
      ENSP00000422705.1, ENST00000506154.1
      Conserved Domains (5) summary
      smart00456
      Location:877909
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9701299
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:9461300
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:753782
      WW; WW domain
      cl14603
      Location:517570
      C2; C2 domain
    3. NM_001284340.1NP_001271269.1  E3 ubiquitin-protein ligase NEDD4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains two alternate in-frame exons, compared to variant 2. The encoded isoform (5) is longer than isoform 2.
      Source sequence(s)
      AC009997, AL832063, AL832359, BC136605, BC144285
      UniProtKB/Swiss-Prot
      P46934
      Conserved Domains (5) summary
      smart00456
      Location:876908
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9691298
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:9451299
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:752781
      WW; WW domain
      cl14603
      Location:513553
      C2; C2 domain
    4. NM_001329212.2NP_001316141.1  E3 ubiquitin-protein ligase NEDD4 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple exons in the 5' UTR, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC009997, AC039057, AL832063, AL833300, D42055
      UniProtKB/TrEMBL
      H0Y8X6
      Related
      ENSP00000422455.1, ENST00000508871.5
    5. NM_006154.4NP_006145.2  E3 ubiquitin-protein ligase NEDD4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple alternate 5' coding exons, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC009997, AL832063, AL833300, D42055
      Consensus CDS
      CCDS45265.1
      UniProtKB/TrEMBL
      H0Y8X6
      Related
      ENSP00000410613.3, ENST00000435532.8
      Conserved Domains (5) summary
      cd04033
      Location:20151
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:474506
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:567896
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:543897
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:350379
      WW; WW domain
    6. NM_198400.3NP_940682.2  E3 ubiquitin-protein ligase NEDD4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform 2.
      Source sequence(s)
      AC009997, AL832063, AL833300, BC035707, BC136605
      Consensus CDS
      CCDS10156.1
      UniProtKB/Swiss-Prot
      P46934
      Related
      ENSP00000345530.2, ENST00000338963.6
      Conserved Domains (4) summary
      smart00456
      Location:821853
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9141243
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:8901244
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:697726
      WW; WW domain

    RNA

    1. NR_104302.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two internal exons and contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009997, AC039057, AL832063, AL832359, AL833293, BC136605, BC144285
      Related
      ENST00000503468.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      55826917..55993612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521625.4XP_011519927.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      See identical proteins and their annotated locations for XP_011519927.1

      UniProtKB/TrEMBL
      H0Y8X6
      Conserved Domains (5) summary
      cd04033
      Location:1100
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:423455
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:516845
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:492846
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:299328
      WW; WW domain
    2. XM_011521626.2XP_011519928.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      See identical proteins and their annotated locations for XP_011519928.1

      UniProtKB/TrEMBL
      H0Y8X6
      Conserved Domains (5) summary
      cd04033
      Location:1100
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:423455
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:516845
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:492846
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:299328
      WW; WW domain
    3. XM_011521624.4XP_011519926.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

      UniProtKB/TrEMBL
      H0Y8X6
      Conserved Domains (5) summary
      cd04033
      Location:15126
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:449481
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:542871
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:518872
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:325354
      WW; WW domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      53630346..53797054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378024.1XP_054233999.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

    2. XM_054378025.1XP_054234000.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

    3. XM_054378023.1XP_054233998.1  E3 ubiquitin-protein ligase NEDD4 isoform X1