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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_051072.1 RefSeqGene
- Range
-
5135..171825
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001284338.2 → NP_001271267.1 E3 ubiquitin-protein ligase NEDD4 isoform 3
See identical proteins and their annotated locations for NP_001271267.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains three alternate in-frame exons, compared to variant 2. The encoded isoform (3) is longer than isoform 2.
- Source sequence(s)
-
AC009997, AC039057
- Consensus CDS
-
CCDS61644.1
- UniProtKB/Swiss-Prot
- A1KY35, A6ND72, A7MD29, B4E2R7, B7ZM59, B7ZM60, B9EGN5, D6RF89, P46934
- Related
- ENSP00000424827.1, ENST00000508342.5
- Conserved Domains (4) summary
-
- smart00456
Location:893 → 925
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:986 → 1315
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- pfam00397
Location:769 → 798
- WW; WW domain
- cl14603
Location:517 → 570
- C2; C2 domain
-
NM_001284339.1 → NP_001271268.1 E3 ubiquitin-protein ligase NEDD4 isoform 4
See identical proteins and their annotated locations for NP_001271268.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) contains three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (4) is longer than isoform 2.
- Source sequence(s)
-
AC009997, AL832063, BC136605, BC144285
- Consensus CDS
-
CCDS61643.1
- UniProtKB/Swiss-Prot
-
P46934
- Related
- ENSP00000422705.1, ENST00000506154.1
- Conserved Domains (5) summary
-
- smart00456
Location:877 → 909
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:970 → 1299
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:946 → 1300
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00397
Location:753 → 782
- WW; WW domain
- cl14603
Location:517 → 570
- C2; C2 domain
-
NM_001284340.1 → NP_001271269.1 E3 ubiquitin-protein ligase NEDD4 isoform 5
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) contains two alternate in-frame exons, compared to variant 2. The encoded isoform (5) is longer than isoform 2.
- Source sequence(s)
-
AC009997, AL832063, AL832359, BC136605, BC144285
- UniProtKB/Swiss-Prot
-
P46934
- Conserved Domains (5) summary
-
- smart00456
Location:876 → 908
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:969 → 1298
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:945 → 1299
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00397
Location:752 → 781
- WW; WW domain
- cl14603
Location:513 → 553
- C2; C2 domain
-
NM_001329212.2 → NP_001316141.1 E3 ubiquitin-protein ligase NEDD4 isoform 6
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple exons in the 5' UTR, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 2.
- Source sequence(s)
-
AC009997, AC039057, AL832063, AL833300, D42055
- UniProtKB/TrEMBL
-
H0Y8X6
- Related
- ENSP00000422455.1, ENST00000508871.5
-
NM_006154.4 → NP_006145.2 E3 ubiquitin-protein ligase NEDD4 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple alternate 5' coding exons, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2.
- Source sequence(s)
-
AC009997, AL832063, AL833300, D42055
- Consensus CDS
-
CCDS45265.1
- UniProtKB/TrEMBL
-
H0Y8X6
- Related
- ENSP00000410613.3, ENST00000435532.8
- Conserved Domains (5) summary
-
- cd04033
Location:20 → 151
- C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
- smart00456
Location:474 → 506
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:567 → 896
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:543 → 897
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00397
Location:350 → 379
- WW; WW domain
-
NM_198400.3 → NP_940682.2 E3 ubiquitin-protein ligase NEDD4 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) encodes isoform 2.
- Source sequence(s)
-
AC009997, AL832063, AL833300, BC035707, BC136605
- Consensus CDS
-
CCDS10156.1
- UniProtKB/Swiss-Prot
-
P46934
- Related
- ENSP00000345530.2, ENST00000338963.6
- Conserved Domains (4) summary
-
- smart00456
Location:821 → 853
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:914 → 1243
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:890 → 1244
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00397
Location:697 → 726
- WW; WW domain
RNA
-
NR_104302.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks two internal exons and contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC009997, AC039057, AL832063, AL832359, AL833293, BC136605, BC144285
- Related
-
ENST00000503468.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000015.10 Reference GRCh38.p14 Primary Assembly
- Range
-
55826917..55993612 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011521625.4 → XP_011519927.1 E3 ubiquitin-protein ligase NEDD4 isoform X2
See identical proteins and their annotated locations for XP_011519927.1
- UniProtKB/TrEMBL
-
H0Y8X6
- Conserved Domains (5) summary
-
- cd04033
Location:1 → 100
- C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
- smart00456
Location:423 → 455
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:516 → 845
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:492 → 846
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00397
Location:299 → 328
- WW; WW domain
-
XM_011521626.2 → XP_011519928.1 E3 ubiquitin-protein ligase NEDD4 isoform X2
See identical proteins and their annotated locations for XP_011519928.1
- UniProtKB/TrEMBL
-
H0Y8X6
- Conserved Domains (5) summary
-
- cd04033
Location:1 → 100
- C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
- smart00456
Location:423 → 455
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:516 → 845
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:492 → 846
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00397
Location:299 → 328
- WW; WW domain
-
XM_011521624.4 → XP_011519926.1 E3 ubiquitin-protein ligase NEDD4 isoform X1
- UniProtKB/TrEMBL
-
H0Y8X6
- Conserved Domains (5) summary
-
- cd04033
Location:15 → 126
- C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
- smart00456
Location:449 → 481
- WW; Domain with 2 conserved Trp (W) residues
- smart00119
Location:542 → 871
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:518 → 872
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00397
Location:325 → 354
- WW; WW domain
Alternate T2T-CHM13v2.0
Genomic
-
NC_060939.1 Alternate T2T-CHM13v2.0
- Range
-
53630346..53797054 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054378024.1 → XP_054233999.1 E3 ubiquitin-protein ligase NEDD4 isoform X2
- UniProtKB/TrEMBL
-
H0Y8X6
-
XM_054378025.1 → XP_054234000.1 E3 ubiquitin-protein ligase NEDD4 isoform X2
- UniProtKB/TrEMBL
-
H0Y8X6
-
XM_054378023.1 → XP_054233998.1 E3 ubiquitin-protein ligase NEDD4 isoform X1
- UniProtKB/TrEMBL
-
H0Y8X6