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    ELOC elongin C [ Homo sapiens (human) ]

    Gene ID: 6921, updated on 9-Dec-2024

    Summary

    Official Symbol
    ELOCprovided by HGNC
    Official Full Name
    elongin Cprovided by HGNC
    Primary source
    HGNC:HGNC:11617
    See related
    Ensembl:ENSG00000154582 MIM:600788; AllianceGenome:HGNC:11617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIII; TCEB1
    Summary
    This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
    Expression
    Ubiquitous expression in testis (RPKM 15.6), brain (RPKM 14.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ELOC in Genome Data Viewer
    Location:
    8q21.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73945119..73972287, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (74374361..74401537, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74857354..74884522, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:74790306-74791183 Neighboring gene long intergenic non-protein coding RNA 1617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27535 Neighboring gene glycogenin 1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74882747-74883636 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:74883637-74884525 and GRCh37_chr8:74884526-74885414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19296 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:74888348-74888563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19297 Neighboring gene transmembrane protein 70 Neighboring gene ribosomal protein S20 pseudogene 21 Neighboring gene DSTN pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 complexes with TCEB1 (ELOC) PubMed
    vif HIV-1 Vif interacts with TCEB1 (Elongin C) as demonstrated by co-immunoprecipitation assay PubMed
    vif ASK1 inhibits the interaction of HIV-1 Vif with ELOB/C in a dose-dependent manner, whereas no significant change is observed in the binding of Vif with CUL5 or CBFbeta PubMed
    vif ASK1 markedly inhibits HIV-1 Vif-induced ubiquitination of APOBEC3G by a reduction in the Vif-ELOC interaction PubMed
    vif HIV-1 Vif, CBF-beta, CUL5, and ELOB/C form a complex that is required for Vif-mediated downregulation of A3G and A3F. CBF-beta regulates HIV-1 infectivity only in the presence of A3G PubMed
    vif An overall crystal structure indicates that the Vif-CBF-beta-CUL5-ELOB-ELOC complex has a U-shape architecture, including the two straight arms Vif-CBF-beta and CUL5 and the bent arm formation between ELOC and CUL5 and Vif interactions PubMed
    vif Mutations in HIV-1 Vif PPLP motif (amino acids 161-164) reduces Vif binding to A3G without affecting its interaction with ElonginC and Cullin5 PubMed
    vif HIV-1 Vif (amino acids 144-149; SLQXLA motif) interacts with cellular proteins Cul5, elongins B and C, and Rbx1 to form an Skp1-Cullin-F-box (SCF)-like complex that allows Vif to interact with APOBEC3G and induce its ubiquitination and degradation PubMed
    vif NMR solution structure indicates that HIV-1 Vif residues L145, A149, and L150 and ELOC residues A99 and L103 are involved in the interaction between Vif and ELOC PubMed
    vif Mutagenesis analysis indicates that HIV-1 Vif residues T123, R127, L145, and A149 and ELOC residues A100, L101, and L104 are involved in the interaction between Vif and ELOC PubMed
    vif Simultaneous substitution of the three Vif-interacting residues L52, W53, and D55 and the two ELOC-interacting residues P41 and H48 in CUL5 impairs the ability of CUL5 to interact with the Vif-CBF-beta-ELOB-ELOC protein complex PubMed
    vif The absence of Vif-CBF-beta reduces the interaction between the CUL5 and the EloC-EloB complex, indicating that the former two proteins have a critical role in promoting assembly of the pentameric complex PubMed
    vif Amino acid residues Vif135-158 have the most binding to the Elongin BC complex and undergo a structural change in the presence of Elongin BC PubMed
    vif The solubility of HIV-1 Vif is significantly enhanced by co-expression of EloB, EloC, and CBF-beta in vitro PubMed
    vif The substitution of Leu64 or Ile66 with serine abolishes the ability of CBF-beta to interact with the Vif-EloB/EloC complex, while the substitution of Thr68 or Tyr69 with alanine has an intermediate effect on the interaction of CBF-beta with the complex PubMed
    vif The interaction of HIV-1 Vif with EloB/EloC complex is important for the binding of Vif to CBF-beta in cells. The Vif SOCS box mutant (SLQ to AAA) significantly disrupt its interaction with the EloB/EloC complex PubMed
    vif A potent small molecular compound VEC-5 protects APOBEC3G, APOBEC3F, and APOBEC3C from HIV-1 Vif-induced degradation and enhances A3G incorporation into HIV-1 virions by inhibiting the interaction between Vif and elongin C PubMed
    vif CUL5/RBX2/ELOB/ELOC/Vif/CBF-beta complex catalyzes polyubiquitin chain formation on A3G in the presence of ubiquitin E2 UBE2R1 (CDC34) or UBCH5b (UBE2D2) PubMed
    vif HIV-1 Vif binding to ElonginC is negatively regulated by serine phosphorylation in the BC-box of the Vif SOCS-box motif, and mutating amino acid S144 in Vif prevents phosphorylation at this site, significantly impairing Vif function and viral replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of elongin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of elongin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    elongin-C
    Names
    RNA polymerase II transcription factor SIII subunit C
    SIII p15
    elongin 15 kDa subunit
    transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
    transcription elongation factor B polypeptide 1
    transcription elongation factor B subunit 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204857.2NP_001191786.1  elongin-C isoform a

      See identical proteins and their annotated locations for NP_001191786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1-7 encode the same protein (isoform a).
      Source sequence(s)
      AC022868, AK057889, AL832244
      Consensus CDS
      CCDS34910.1
      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Related
      ENSP00000428334.1, ENST00000518127.5
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    2. NM_001204858.2NP_001191787.1  elongin-C isoform a

      See identical proteins and their annotated locations for NP_001191787.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate exon in the 5' UTR compared to variant 1. Variants 1-7 encode the same protein (isoform a).
      Source sequence(s)
      AC022868, AK057889, BG767430, DA537957
      Consensus CDS
      CCDS34910.1
      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    3. NM_001204859.2NP_001191788.1  elongin-C isoform a

      See identical proteins and their annotated locations for NP_001191788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate exon in the 5' UTR compared to variant 1. Variants 1-7 encode the same protein (isoform a).
      Source sequence(s)
      AC022868, AK057889, BG767430
      Consensus CDS
      CCDS34910.1
      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    4. NM_001204860.2NP_001191789.1  elongin-C isoform a

      See identical proteins and their annotated locations for NP_001191789.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-7 encode the same protein (isoform a).
      Source sequence(s)
      AC022868, AK057889, BG428202, CX166843
      Consensus CDS
      CCDS34910.1
      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Related
      ENSP00000509184.1, ENST00000687224.1
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    5. NM_001204861.2NP_001191790.1  elongin-C isoform a

      See identical proteins and their annotated locations for NP_001191790.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-7 encode the same protein (isoform a).
      Source sequence(s)
      AC022868, AK057889, BM720777
      Consensus CDS
      CCDS34910.1
      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Related
      ENSP00000428074.1, ENST00000523815.5
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    6. NM_001204862.2NP_001191791.1  elongin-C isoform a

      See identical proteins and their annotated locations for NP_001191791.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-7 encode the same protein (isoform a).
      Source sequence(s)
      AC022868, AK057889, BM720777, CX166168
      Consensus CDS
      CCDS34910.1
      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Related
      ENSP00000478121.1, ENST00000622804.2
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    7. NM_001204863.2NP_001191792.1  elongin-C isoform b

      See identical proteins and their annotated locations for NP_001191792.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an internal exon that results in use of a downstream start codon compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform a. Variants 8 and 9 encode the same protein.
      Source sequence(s)
      AC022868, AK057889, BG703267, BX649138
      Consensus CDS
      CCDS56539.1
      UniProtKB/Swiss-Prot
      Q15369
      Related
      ENSP00000430224.1, ENST00000520210.1
      Conserved Domains (1) summary
      cd18321
      Location:296
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    8. NM_001204864.2NP_001191793.1  elongin-C isoform b

      See identical proteins and their annotated locations for NP_001191793.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an internal segment in the 5' region that results in use of downstream start codon compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform a. Variants 8 and 9 encode the same protein.
      Source sequence(s)
      AC022868, AK057889, BG428202, CF129635
      Consensus CDS
      CCDS56539.1
      UniProtKB/Swiss-Prot
      Q15369
      Related
      ENSP00000509989.1, ENST00000688584.1
      Conserved Domains (1) summary
      cd18321
      Location:296
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    9. NM_005648.4NP_005639.1  elongin-C isoform a

      See identical proteins and their annotated locations for NP_005639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-7 encode the same protein (isoform a).
      Source sequence(s)
      AC022868, AK057889, BM821650
      Consensus CDS
      CCDS34910.1
      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Related
      ENSP00000428171.1, ENST00000520242.6
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      73945119..73972287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422158.1XP_047278114.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    2. XM_047422157.1XP_047278113.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Related
      ENSP00000429906.1, ENST00000522337.5
    3. XM_011517581.3XP_011515883.1  elongin-C isoform X1

      See identical proteins and their annotated locations for XP_011515883.1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
      Related
      ENSP00000284811.8, ENST00000284811.12
      Conserved Domains (1) summary
      cd18321
      Location:18112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    4. XM_047422155.1XP_047278111.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    5. XM_047422162.1XP_047278118.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    6. XM_047422156.1XP_047278112.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    7. XM_047422163.1XP_047278119.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    8. XM_047422164.1XP_047278120.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    9. XM_047422161.1XP_047278117.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    10. XM_047422160.1XP_047278116.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    11. XM_047422159.1XP_047278115.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      74374361..74401537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361116.1XP_054217091.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    2. XM_054361112.1XP_054217087.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    3. XM_054361115.1XP_054217090.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    4. XM_054361113.1XP_054217088.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    5. XM_054361120.1XP_054217095.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    6. XM_054361114.1XP_054217089.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    7. XM_054361121.1XP_054217096.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    8. XM_054361122.1XP_054217097.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    9. XM_054361119.1XP_054217094.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    10. XM_054361118.1XP_054217093.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6
    11. XM_054361117.1XP_054217092.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      E5RGD9, Q15369, Q567Q6