CCT4 chaperonin-containing T-complex subunit CCT4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CCT4
Official Full Name: chaperonin-containing T-complex subunit CCT4
Primary source: SGD:S000002302
Locus tag: YDL143W
See related: AllianceGenome:SGD:S000002302; FungiDB:YDL143W; VEuPathDB:YDL143W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ANC2; TCP4
Summary: Enables unfolded protein binding activity. Involved in protein folding. Part of chaperonin-containing T-complex. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CCT4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (199996..201582)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The values of the observed rate constants corresponding to the burst phases are found to decrease with increasing ATP and K(+) concentrations, thereby indicating that the apo state of CCT/TRiC is in equilibrium between several conformations and that "conformational selection" by ATP takes place before hydrolysis.
Title: Transient Kinetic Analysis of ATP Hydrolysis by the CCT/TRiC Chaperonin.
support for the sequential model for ATP-dependent allosteric transitions in CCT
Title: ATP-induced allostery in the eukaryotic chaperonin CCT is abolished by the mutation G345D in CCT4 that renders yeast temperature-sensitive for growth.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone mediated protein folding independent of cofactor	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	IEA Inferred from Electronic Annotation more info
part_of chaperonin-containing T-complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chaperonin-containing T-complex subunit CCT4

NP_010138.1

Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

199996..201582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180203.1 → NP_010138.1 TPA: chaperonin-containing T-complex subunit CCT4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010138.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRK5, P39078, Q07561

UniProtKB/TrEMBL

A6ZXI4, B3LH34, C7GKZ5, C8Z6F9, G2WC18, N1P959

Conserved Domains (1) summary

TIGR02342
Location:11 → 528

chap_CCT_delta; T-complex protein 1, delta subunit