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    STMN2 stathmin 2 [ Homo sapiens (human) ]

    Gene ID: 11075, updated on 3-Dec-2024

    Summary

    Official Symbol
    STMN2provided by HGNC
    Official Full Name
    stathmin 2provided by HGNC
    Primary source
    HGNC:HGNC:10577
    See related
    Ensembl:ENSG00000104435 MIM:600621; AllianceGenome:HGNC:10577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCG10; SCGN10
    Summary
    This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
    Expression
    Biased expression in brain (RPKM 155.5) and adrenal (RPKM 33.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STMN2 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (79611117..79666158)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80042462..80097513)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80523352..80578393)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 12123 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:80305081-80305610 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:80375461-80376660 Neighboring gene ribosomal protein L3 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19310 Neighboring gene uncharacterized LOC105375916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80578153-80578695 Neighboring gene Sharpr-MPRA regulatory region 13175 Neighboring gene uncharacterized LOC124901965 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:80635352-80636551 Neighboring gene uncharacterized LOC107986893

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ34868, FLJ50995

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    stathmin-2
    Names
    neuron-specific growth-associated protein
    neuronal growth-associated protein (silencer element)
    stathmin-like 2
    superior cervical ganglia, neural specific 10
    superior cervical ganglion-10 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199214.2NP_001186143.1  stathmin-2 isoform 1

      See identical proteins and their annotated locations for NP_001186143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC016240, BQ069488, DC319376
      Consensus CDS
      CCDS56542.1
      UniProtKB/Swiss-Prot
      Q93045
      Related
      ENSP00000429243.1, ENST00000518111.5
      Conserved Domains (1) summary
      pfam00836
      Location:39163
      Stathmin; Stathmin family
    2. NM_007029.4NP_008960.2  stathmin-2 isoform 2

      See identical proteins and their annotated locations for NP_008960.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC016240, AC025599, DC319376
      Consensus CDS
      CCDS43748.1
      UniProtKB/Swiss-Prot
      A8K9M2, G3V110, O14952, Q6PK68, Q93045
      UniProtKB/TrEMBL
      B7Z4N6, C9J0X6
      Related
      ENSP00000220876.7, ENST00000220876.12
      Conserved Domains (1) summary
      pfam00836
      Location:39174
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      79611117..79666158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251142.3XP_005251199.1  stathmin-2 isoform X1

      See identical proteins and their annotated locations for XP_005251199.1

      UniProtKB/TrEMBL
      B7Z4N6, C9J0X6
      Conserved Domains (1) summary
      pfam00836
      Location:34169
      Stathmin; Stathmin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      80042462..80097513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359640.1XP_054215615.1  stathmin-2 isoform X1

      UniProtKB/TrEMBL
      B7Z4N6, C9J0X6