U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GABPB1 GA binding protein transcription factor subunit beta 1 [ Homo sapiens (human) ]

    Gene ID: 2553, updated on 3-Dec-2024

    Summary

    Official Symbol
    GABPB1provided by HGNC
    Official Full Name
    GA binding protein transcription factor subunit beta 1provided by HGNC
    Primary source
    HGNC:HGNC:4074
    See related
    Ensembl:ENSG00000104064 MIM:600610; AllianceGenome:HGNC:4074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E4TF1; GABPB; BABPB2; E4TF1B; GABPB2; NRF2B1; NRF2B2; GABPB-1; E4TF1-47; E4TF1-53
    Summary
    This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. The gene on Hsa1q was named GABPB2 and the gene on Hsa15q was named GABPB1. [24 Sep 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.9), lymph node (RPKM 6.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GABPB1 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (50275389..50355198, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (48083628..48163356, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (50567586..50647395, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6424 Neighboring gene solute carrier family 27 member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:50502954-50503533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:50544247-50544748 Neighboring gene RNA, 7SL, cytoplasmic 494, pseudogene Neighboring gene histidine decarboxylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6426 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:50647177-50647800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9392 Neighboring gene GABPB1 intronic transcript Neighboring gene GABPB1 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 94, pseudogene Neighboring gene microRNA 4712 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:50674110-50674285 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:50676534-50676699 Neighboring gene adenosylhomocysteinase pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of GA binding protein transcription factor, beta subunit 1 (GABPB1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GA-binding protein subunit beta-1
    Names
    GA binding protein transcription factor beta subunit 1
    GABP subunit beta-2
    nuclear respiratory factor 2
    transcription factor E4TF1-47
    transcription factor E4TF1-53
    NP_001307839.1
    NP_001307844.1
    NP_002032.2
    NP_005245.2
    NP_057738.1
    NP_057739.1
    NP_852092.1
    XP_005254331.1
    XP_011519728.1
    XP_016877542.1
    XP_024305651.1
    XP_024305654.1
    XP_047288292.1
    XP_047288293.1
    XP_054233630.1
    XP_054233631.1
    XP_054233632.1
    XP_054233633.1
    XP_054233634.1
    XP_054233635.1
    XP_054233636.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029475.2 RefSeqGene

      Range
      5211..85020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320910.2NP_001307839.1  GA-binding protein subunit beta-1 isoform beta 1

      Status: REVIEWED

      Source sequence(s)
      AC022087
      Consensus CDS
      CCDS32239.1
      UniProtKB/Swiss-Prot
      A8IE52, Q06545, Q06547, Q12940, Q12941, Q12942, Q8IYD0
      UniProtKB/TrEMBL
      B7Z726
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:341390
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    2. NM_001320915.2NP_001307844.1  GA-binding protein subunit beta-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022087
      UniProtKB/TrEMBL
      B7Z726
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:340389
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    3. NM_002041.5NP_002032.2  GA-binding protein subunit beta-1 isoform gamma 1

      See identical proteins and their annotated locations for NP_002032.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma 1) uses an alternate in-frame splice site in the 3' coding region, compared to variant beta 1, resulting in a shorter isoform (gamma 1).
      Source sequence(s)
      DA156248, U13047
      Consensus CDS
      CCDS45258.1
      UniProtKB/TrEMBL
      B7Z726
      Related
      ENSP00000395771.2, ENST00000429662.6
      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
    4. NM_005254.6NP_005245.2  GA-binding protein subunit beta-1 isoform beta 1

      See identical proteins and their annotated locations for NP_005245.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta 1) encodes the longest isoform (beta 1).
      Source sequence(s)
      AC022087, AI631183, BC036080, DA156248, U13045
      Consensus CDS
      CCDS32239.1
      UniProtKB/Swiss-Prot
      A8IE52, Q06545, Q06547, Q12940, Q12941, Q12942, Q8IYD0
      UniProtKB/TrEMBL
      B7Z726
      Related
      ENSP00000220429.8, ENST00000220429.12
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:341390
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    5. NM_016654.5NP_057738.1  GA-binding protein subunit beta-1 isoform beta 2

      See identical proteins and their annotated locations for NP_057738.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta 2) lacks an alternate in-frame segment, compared to variant beta 1, resulting in a shorter isoform (beta 2) that lacks a 12-amino acid serine-rich region, compared to isoform beta 1.
      Source sequence(s)
      AC022087, AI631183, BC036080, D13317, DA156248
      Consensus CDS
      CCDS10135.1
      UniProtKB/TrEMBL
      B7Z726
      Related
      ENSP00000370259.3, ENST00000380877.8
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:329378
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    6. NM_016655.5NP_057739.1  GA-binding protein subunit beta-1 isoform gamma 2

      See identical proteins and their annotated locations for NP_057739.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma 2) contains multiple differences compared to variant beta 1, resulting in a shorter isoform (gamma 2) that lacks a 12-amino acid serine-rich region, compared to isoform beta 1. Both this variant (gamma 2) and gamma 3 encode the same isoform (gamma 2), however, they differ in the 5' UTR.
      Source sequence(s)
      DA156248, U13047, U13048
      Consensus CDS
      CCDS10136.1
      UniProtKB/TrEMBL
      B7Z726
      Related
      ENSP00000379728.3, ENST00000396464.7
      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
    7. NM_181427.4NP_852092.1  GA-binding protein subunit beta-1 isoform gamma 2

      See identical proteins and their annotated locations for NP_852092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma 3) contains multiple differences compared to variant beta 1, resulting in a shorter isoform (gamma 2) that lacks a 12-amino acid serine-rich region, compared to isoform beta 1. Both this variant (gamma 3) and gamma 2 encode the same isoform (gamma 2), however, they differ in the 5' UTR.
      Source sequence(s)
      DA156248, DA502761, U13048
      Consensus CDS
      CCDS10136.1
      UniProtKB/TrEMBL
      B7Z726
      Related
      ENSP00000351923.4, ENST00000359031.8
      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      50275389..50355198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521426.4XP_011519728.1  GA-binding protein subunit beta-1 isoform X7

      See identical proteins and their annotated locations for XP_011519728.1

      UniProtKB/TrEMBL
      B7Z726
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:328377
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    2. XM_024449886.2XP_024305654.1  GA-binding protein subunit beta-1 isoform X4

      UniProtKB/TrEMBL
      B7Z726
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:340389
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    3. XM_017022053.3XP_016877542.1  GA-binding protein subunit beta-1 isoform X6

      UniProtKB/TrEMBL
      B7Z726
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:329378
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    4. XM_024449883.2XP_024305651.1  GA-binding protein subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      B7Z726
      Conserved Domains (3) summary
      cd00204
      Location:39161
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:4373
      ANK; ANK repeat [structural motif]
      cl25742
      Location:328394
      ERM; Ezrin/radixin/moesin family
    5. XM_047432337.1XP_047288293.1  GA-binding protein subunit beta-1 isoform X5

      UniProtKB/TrEMBL
      B7Z726
    6. XM_005254274.5XP_005254331.1  GA-binding protein subunit beta-1 isoform X3

      See identical proteins and their annotated locations for XP_005254331.1

      UniProtKB/Swiss-Prot
      A8IE52, Q06545, Q06547, Q12940, Q12941, Q12942, Q8IYD0
      UniProtKB/TrEMBL
      B7Z726
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam16566
      Location:341390
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    7. XM_047432336.1XP_047288292.1  GA-binding protein subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      B7Z726

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      48083628..48163356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377661.1XP_054233636.1  GA-binding protein subunit beta-1 isoform X7

      UniProtKB/TrEMBL
      B7Z726
    2. XM_054377658.1XP_054233633.1  GA-binding protein subunit beta-1 isoform X4

      UniProtKB/TrEMBL
      B7Z726
    3. XM_054377660.1XP_054233635.1  GA-binding protein subunit beta-1 isoform X6

      UniProtKB/TrEMBL
      B7Z726
    4. XM_054377656.1XP_054233631.1  GA-binding protein subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      B7Z726
    5. XM_054377659.1XP_054233634.1  GA-binding protein subunit beta-1 isoform X5

      UniProtKB/TrEMBL
      B7Z726
    6. XM_054377657.1XP_054233632.1  GA-binding protein subunit beta-1 isoform X3

      UniProtKB/Swiss-Prot
      A8IE52, Q06545, Q06547, Q12940, Q12941, Q12942, Q8IYD0
      UniProtKB/TrEMBL
      B7Z726
    7. XM_054377655.1XP_054233630.1  GA-binding protein subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      B7Z726