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    ONECUT1 one cut homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 3175, updated on 9-Dec-2024

    Summary

    Official Symbol
    ONECUT1provided by HGNC
    Official Full Name
    one cut homeobox 1provided by HGNC
    Primary source
    HGNC:HGNC:8138
    See related
    Ensembl:ENSG00000169856 MIM:604164; AllianceGenome:HGNC:8138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNF6; HNF-6; HNF6A
    Summary
    This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in liver (RPKM 2.0), gall bladder (RPKM 1.7) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ONECUT1 in Genome Data Viewer
    Location:
    15q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (52755053..52790336, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (50563333..50598640, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (53047250..53082533, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860078-52860826 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860827-52861573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9432 Neighboring gene cAMP regulated phosphoprotein 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52904295-52904794 Neighboring gene atos homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9434 Neighboring gene NANOG hESC enhancer GRCh37_chr15:52963789-52964290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6450 Neighboring gene uncharacterized LOC105370821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52979459-52979959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9437 Neighboring gene Sharpr-MPRA regulatory region 217 Neighboring gene uncharacterized LOC105370824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:53082820-53083588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:53083589-53084356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:53086613-53087310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:53087311-53088006 Neighboring gene uncharacterized LOC101928499 Neighboring gene uncharacterized LOC107983981

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of one cut homeobox 1 (ONECUT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreatic A cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreatic D cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type B pancreatic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    hepatocyte nuclear factor 6
    Names
    hepatocyte nuclear factor 6, alpha
    one cut domain family member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004498.4NP_004489.1  hepatocyte nuclear factor 6

      See identical proteins and their annotated locations for NP_004489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AA699732, AC016044, BM679470, U96173
      Consensus CDS
      CCDS10150.1
      UniProtKB/Swiss-Prot
      B2RTV4, Q99744, Q9UBC0, Q9UMR6
      UniProtKB/TrEMBL
      B2CNW3
      Related
      ENSP00000302630.4, ENST00000305901.7
      Conserved Domains (2) summary
      smart00389
      Location:385440
      HOX; Homeodomain
      pfam02376
      Location:290362
      CUT; CUT domain

    RNA

    1. NR_073510.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA699732, AC016044, BM679470, BX118406, U96173

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      52755053..52790336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      50563333..50598640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)