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    ERG26 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERG26
    Official Full Name
    sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
    Primary source
    SGD:S000002969
    Locus tag
    YGL001C
    See related
    AllianceGenome:SGD:S000002969; FungiDB:YGL001C; VEuPathDB:YGL001C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity and sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane. Used to study cancer. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent steroid dehydrogenase-like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERG26 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (495453..496502, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Cdh1p Neighboring gene Erp6p Neighboring gene protein-lysine N-methyltransferase Neighboring gene Swc4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Candida albicans ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) is essential for growth. Aaron KE, et al. FEMS Yeast Res, 2001 Jul. PMID 12702354
    2. Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Gachotte D, et al. Proc Natl Acad Sci U S A, 1998 Nov 10. PMID 9811880, Free PMC Article
    3. Hypomorphic temperature-sensitive alleles of NSDHL cause CK syndrome. McLarren KW, et al. Am J Hum Genet, 2010 Dec 10. PMID 21129721, Free PMC Article
    4. The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. Baudry K, et al. J Biol Chem, 2001 Apr 20. PMID 11279045
    5. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Mo C, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12119386, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
    NP_011514.1
    • C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      495453..496502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180866.1 → NP_011514.1  TPA: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011514.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUD7, P53199
      UniProtKB/TrEMBL
      A6ZUZ2, B3LIL6, B5VIW1, C7GK71, C8Z8P4, G2WE93, N1P3D7
      Conserved Domains (1) summary
      cd09813
      Location:6 → 345
      3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53199.1

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