MET13 methylenetetrahydrofolate reductase (NAD(P)H) MET13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET13
Official Full Name: methylenetetrahydrofolate reductase (NAD(P)H) MET13
Primary source: SGD:S000003093
Locus tag: YGL125W
See related: AllianceGenome:SGD:S000003093; FungiDB:YGL125W; VEuPathDB:YGL125W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MET11; MRPL45
Summary: Enables methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in methionine biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MET13 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (272520..274322)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IDA Inferred from Direct Assay more info	PubMed
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methionine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: methylenetetrahydrofolate reductase (NAD(P)H) MET13

NP_011390.2

EC 1.5.1.53

Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

272520..274322

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180990.1 → NP_011390.2 TPA: methylenetetrahydrofolate reductase (NAD(P)H) MET13 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011390.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU23, O94090, P53128, Q92318

UniProtKB/TrEMBL

A6ZU57, B3LHI5, C7GX60, C8Z8C5, N1P5B8

Conserved Domains (1) summary

cl00246
Location:19 → 586

MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...