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    KAP114 karyopherin KAP114 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852610, updated on 17-Dec-2024

    Summary

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    Official Symbol
    KAP114
    Official Full Name
    karyopherin KAP114
    Primary source
    SGD:S000003210
    Locus tag
    YGL241W
    See related
    AllianceGenome:SGD:S000003210; FungiDB:YGL241W; VEuPathDB:YGL241W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO9 (importin 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KAP114 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (45445..48459)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-specific adenosine deaminase Neighboring gene Ank1p Neighboring gene anaphase promoting complex subunit DOC1 Neighboring gene importin-alpha export receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein. Liao CC, et al. Nat Commun, 2023 Sep 8. PMID 37684250, Free PMC Article
    2. A role for nucleosome assembly protein 1 in the nuclear transport of histones H2A and H2B. Mosammaparast N, et al. EMBO J, 2002 Dec 2. PMID 12456659, Free PMC Article
    3. Involvement of nucleocytoplasmic shuttling of yeast Nap1 in mitotic progression. Miyaji-Yamaguchi M, et al. Mol Cell Biol, 2003 Sep. PMID 12944491, Free PMC Article
    4. The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein. Morehouse H, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10535958, Free PMC Article
    5. Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Jiou J, et al. Proc Natl Acad Sci U S A, 2023 Jul 18. PMID 37450495, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein.
      Title: Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein.
    2. It is proposed that sumoylation occurs at the site of Kap114 cargo function and that small ubiquitin-related modifier is a cargo release factor involved in intranuclear targeting.
      Title: Sumoylation regulates Kap114-mediated nuclear transport.
    3. Kap114p, responsible for the nuclear import of histones H2A and H2B, modulates the deposition of histones H2A and H2B by the histone chaperone Nap1p.
      Title: Modulation of histone deposition by the karyopherin kap114.
    4. TFIIB nuclear import is mediated by Kap114p
      Title: Nuclear import of TFIIB is mediated by Kap114p, a karyopherin with multiple cargo-binding domains.
    5. The KAP114 protein functions is in a parallel import pathway for H2A and H2B.
      Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    karyopherin KAP114
    NP_011273.1
    • Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      45445..48459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181107.1 → NP_011273.1  TPA: karyopherin KAP114 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011273.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV94, P53067
      UniProtKB/TrEMBL
      C7GNY7, N1P3A8
      Conserved Domains (1) summary
      COG5657
      Location:10 → 165
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53067.1

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