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    translation initiation factor 2A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852945, updated on 17-Dec-2024

    Summary

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    Official Full Name
    translation initiation factor 2A
    Primary source
    SGD:S000003286
    Locus tag
    YGR054W
    See related
    AllianceGenome:SGD:S000003286; FungiDB:YGR054W; VEuPathDB:YGR054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation initiation factor activity. Involved in translational initiation. Acts upstream of or within negative regulation of translation. Located in cytosolic ribosome. Part of cytosolic small ribosomal subunit. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (596693..598621)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene protein kinase FMP48 Neighboring gene Mco32p Neighboring gene Mup1p Neighboring gene RSC subunit protein RSC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discrimination between initiation and elongation of protein biosynthesis in yeast: identity assured by a nucleotide modification in the initiator tRNA. Förster C, et al. Nucleic Acids Res, 1993 Dec 11. PMID 8284215, Free PMC Article
    2. Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response. Bou-Nader C, et al. Proc Natl Acad Sci U S A, 2024 Aug 27. PMID 39163341,
    3. A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae. Reineke LC, et al. J Biol Chem, 2008 Jul 4. PMID 18460470, Free PMC Article
    4. Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression. Reineke LC, et al. RNA, 2009 Dec. PMID 19861427, Free PMC Article
    5. The structural basis of translational control by eIF2 phosphorylation. Adomavicius T, et al. Nat Commun, 2019 May 13. PMID 31086188, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that eIF2A acts as a switch to regulate IRES-mediated translation, and eEF1A may be an important mediator of translational activation during ethanol stress.
      Title: Insights into the role of yeast eIF2A in IRES-mediated translation.
    2. data also indicate that eIF2A-mediated repression is not specific to the URE2 IRES element, as both the GIC1 and PAB1 IRES elements are repressed by eIF2A.
      Title: Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression.
    3. Robust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast.
      Title: Robust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae.
    4. Following 80S complex formation, GTP hydrolysis by eIF5B enables the release of both eIF5B and eIF1A, and the ribosome enters the elongation phase of protein synthesis
      Title: Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor 2A
    NP_011568.3
    • Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80S ribosomes, and interacts genetically with both eIF5b and eIF4E; physically interacts with Ssd1p, and associates with mRNAs encoding proteins required for cell wall organization, and some of which require the presence of Ssd1p; translational repressor of cell wall-related proteins; interacts physically and genetically with Xrn1p; homologous to mammalian eIF2A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      596693..598621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181183.4 → NP_011568.3  TPA: translation initiation factor 2A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011568.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUI9, P53235, Q45U32
      UniProtKB/TrEMBL
      A6ZV39, B3LIG9, C7GXN7, C8Z8U8, G2WEE1, N1P5R3
      Conserved Domains (2) summary
      COG5354
      Location:1 → 637
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      sd00039
      Location:235 → 281
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53235.1

    Gene LinkOut

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