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    NMU neuromedin U [ Homo sapiens (human) ]

    Gene ID: 10874, updated on 27-Nov-2024

    Summary

    Official Symbol
    NMUprovided by HGNC
    Official Full Name
    neuromedin Uprovided by HGNC
    Primary source
    HGNC:HGNC:7859
    See related
    Ensembl:ENSG00000109255 MIM:605103; AllianceGenome:HGNC:7859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in esophagus (RPKM 5.6), skin (RPKM 5.5) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NMU in Genome Data Viewer
    Location:
    4q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (55595231..55636793, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59083363..59124965, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56461398..56502960, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene clock circadian regulator Neighboring gene uncharacterized LOC124900704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15442 Neighboring gene phosducin like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15443 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501035-56501786 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501787-56502538 Neighboring gene uncharacterized LOC105377660 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:56573715-56574216 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:56574217-56574716 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1625 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1626 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1627 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1628 Neighboring gene Sharpr-MPRA regulatory region 7030 Neighboring gene RNA, U6 small nuclear 276, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuromedin U receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables type 1 neuromedin U receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables type 2 neuromedin U receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neuromedin-U
    Names
    neuromedin U precursor-related peptide/neuromedin U preproprotein
    prepro-NMU

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001292045.2NP_001278974.1  neuromedin-U isoform 2 precursor

      See identical proteins and their annotated locations for NP_001278974.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1. This isoform (2) may undergo processing similar to isoform 1 to generate mature peptide.
      Source sequence(s)
      BC012908, BI603117, BQ049320
      Consensus CDS
      CCDS75125.1
      UniProtKB/TrEMBL
      A0A0B4J202, D6RBC9
      Related
      ENSP00000422399.1, ENST00000511469.5
      Conserved Domains (1) summary
      smart00084
      Location:126150
      NMU; Neuromedin U
    2. NM_001292046.2NP_001278975.1  neuromedin-U isoform 3 precursor

      See identical proteins and their annotated locations for NP_001278975.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter than isoform 1.
      Source sequence(s)
      AJ510133, BC012908, BF185217, BI603117, BQ049320
      Consensus CDS
      CCDS77914.1
      UniProtKB/TrEMBL
      E9PDJ7
      Related
      ENSP00000422870.1, ENST00000507338.1
      Conserved Domains (1) summary
      smart00084
      Location:119141
      NMU; Neuromedin U
    3. NM_006681.4NP_006672.1  neuromedin-U isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_006672.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC012908, BI603117, X76029
      Consensus CDS
      CCDS3501.1
      UniProtKB/Swiss-Prot
      P48645
      UniProtKB/TrEMBL
      A0A250SH36, D6RBC9
      Related
      ENSP00000264218.3, ENST00000264218.7
      Conserved Domains (1) summary
      smart00084
      Location:142166
      NMU; Neuromedin U

    RNA

    1. NR_120489.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC024243, BC012908, CN343322

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      55595231..55636793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449544.1XP_047305500.1  neuromedin-U isoform X3

    2. XM_011534368.4XP_011532670.1  neuromedin-U isoform X2

      See identical proteins and their annotated locations for XP_011532670.1

      UniProtKB/TrEMBL
      Q86WB4
      Conserved Domains (1) summary
      smart00084
      Location:108132
      NMU; Neuromedin U
    3. XM_011534367.3XP_011532669.1  neuromedin-U isoform X1

      Conserved Domains (1) summary
      smart00084
      Location:125149
      NMU; Neuromedin U

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      59083363..59124965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348801.1XP_054204776.1  neuromedin-U isoform X3

    2. XM_054348800.1XP_054204775.1  neuromedin-U isoform X2

    3. XM_054348799.1XP_054204774.1  neuromedin-U isoform X1