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    SPINT3 serine peptidase inhibitor, Kunitz type 3 [ Homo sapiens (human) ]

    Gene ID: 10816, updated on 27-Nov-2024

    Summary

    Official Symbol
    SPINT3provided by HGNC
    Official Full Name
    serine peptidase inhibitor, Kunitz type 3provided by HGNC
    Primary source
    HGNC:HGNC:11248
    See related
    Ensembl:ENSG00000101446 MIM:613941; AllianceGenome:HGNC:11248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HKIB9
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SPINT3 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45512461..45515622, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47248342..47251497, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44141101..44144262, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12959 Neighboring gene WAP four-disulfide core domain 2 Neighboring gene uncharacterized LOC107987282 Neighboring gene ribosomal protein L5 pseudogene 2 Neighboring gene EPPIN-WFDC6 readthrough Neighboring gene WAP four-disulfide core domain 6 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 21

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Voxelwise genome-wide association study (vGWAS).
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    kunitz-type protease inhibitor 3
    Names
    serine protease inhibitor, Kunitz type, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006652.2NP_006643.1  kunitz-type protease inhibitor 3 precursor

      See identical proteins and their annotated locations for NP_006643.1

      Status: VALIDATED

      Source sequence(s)
      AL031663, AY372172, BX088813
      Consensus CDS
      CCDS46608.1
      UniProtKB/Swiss-Prot
      A6NCQ6, P49223, Q6UDR8, Q96KK2
      Related
      ENSP00000217428.6, ENST00000217428.7
      Conserved Domains (1) summary
      cd00109
      Location:3487
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      45512461..45515622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      47248342..47251497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)