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    NME4 NME/NM23 nucleoside diphosphate kinase 4 [ Homo sapiens (human) ]

    Gene ID: 4833, updated on 27-Nov-2024

    Summary

    Official Symbol
    NME4provided by HGNC
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:7852
    See related
    Ensembl:ENSG00000103202 MIM:601818; AllianceGenome:HGNC:7852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDPK-D; NM23H4; nm23-H4
    Summary
    The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 37.4), fat (RPKM 31.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NME4 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (396729..400754)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (392618..396999)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (446729..450754)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:422268-422839 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:431071-431970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6916 Neighboring gene uncharacterized LOC100134368 Neighboring gene post-GPI attachment to proteins 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:440484-440661 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:449109-449694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:450865-451450 Neighboring gene 2,4-dienoyl-CoA reductase 2 Neighboring gene RAB11 family interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:492123-492661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495322-495822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495823-496323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516240-516869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516870-517498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:532003-532508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:534533-535038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:535039-535544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:537093-537971 Neighboring gene uncharacterized LOC107987417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:542303-542924

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: DECR2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cardiolipin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleoside metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    nucleoside diphosphate kinase, mitochondrial
    Names
    NDK
    NDP kinase D
    NDP kinase, mitochondrial
    NDPKD
    non-metastatic cells 4, protein expressed in
    nucleoside diphosphate kinase D
    NP_001273362.1
    NP_001273364.1
    NP_001273365.1
    NP_001273367.1
    NP_001273368.1
    NP_001273369.1
    NP_005000.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286433.2NP_001273362.1  nucleoside diphosphate kinase, mitochondrial isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC004880, BC017067, HY182358
      Consensus CDS
      CCDS73797.1
      UniProtKB/TrEMBL
      A0A087WVT9
      Related
      ENSP00000479681.1, ENST00000621774.4
      Conserved Domains (2) summary
      cd04413
      Location:38133
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
      pfam00334
      Location:38138
      NDK; Nucleoside diphosphate kinase
    2. NM_001286435.2NP_001273364.1  nucleoside diphosphate kinase, mitochondrial isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to isoform 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC004880, BC017067, BE266496
      UniProtKB/TrEMBL
      H0Y6J0
      Related
      ENSP00000405925.1, ENST00000433358.5
      Conserved Domains (2) summary
      cd04413
      Location:38145
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
      pfam00334
      Location:38159
      NDK; Nucleoside diphosphate kinase
    3. NM_001286436.2NP_001273365.1  nucleoside diphosphate kinase, mitochondrial isoform d

      See identical proteins and their annotated locations for NP_001273365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
      Source sequence(s)
      BC004880, BQ650649, CB143020, Z97634
      Consensus CDS
      CCDS66886.1
      UniProtKB/Swiss-Prot
      O00746
      Related
      ENSP00000380834.1, ENST00000397722.5
      Conserved Domains (1) summary
      cd04413
      Location:197
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    4. NM_001286438.2NP_001273367.1  nucleoside diphosphate kinase, mitochondrial isoform d

      See identical proteins and their annotated locations for NP_001273367.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
      Source sequence(s)
      BC004880, BC017067, BP328820
      Consensus CDS
      CCDS66886.1
      UniProtKB/Swiss-Prot
      O00746
      Conserved Domains (1) summary
      cd04413
      Location:197
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    5. NM_001286439.2NP_001273368.1  nucleoside diphosphate kinase, mitochondrial isoform d

      See identical proteins and their annotated locations for NP_001273368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
      Source sequence(s)
      BC004880, BC017067, CF126980
      Consensus CDS
      CCDS66886.1
      UniProtKB/Swiss-Prot
      O00746
      Related
      ENSP00000479996.1, ENST00000620944.4
      Conserved Domains (1) summary
      cd04413
      Location:197
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    6. NM_001286440.2NP_001273369.1  nucleoside diphosphate kinase, mitochondrial isoform d

      See identical proteins and their annotated locations for NP_001273369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate exon and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
      Source sequence(s)
      BC004880, BG472605, BQ932845
      Consensus CDS
      CCDS66886.1
      UniProtKB/Swiss-Prot
      O00746
      Related
      ENSP00000389048.1, ENST00000450036.1
      Conserved Domains (1) summary
      cd04413
      Location:197
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    7. NM_005009.3NP_005000.1  nucleoside diphosphate kinase, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_005000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC004880, BC017067
      Consensus CDS
      CCDS10408.1
      UniProtKB/Swiss-Prot
      A2IDD0, O00746, Q5U0M9
      UniProtKB/TrEMBL
      Q4TT34
      Related
      ENSP00000219479.2, ENST00000219479.7
      Conserved Domains (2) summary
      smart00562
      Location:38172
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04413
      Location:38167
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      396729..400754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      392618..396999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)