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    RRP3 RNA-dependent ATPase RRP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RRP3
    Official Full Name
    RNA-dependent ATPase RRP3
    Primary source
    SGD:S000001107
    Locus tag
    YHR065C
    See related
    AllianceGenome:SGD:S000001107; FungiDB:YHR065C; VEuPathDB:YHR065C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA helicase activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human DDX47 (DEAD-box helicase 47). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RRP3 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (227532..229037, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene 2-dehydropantoate 2-reductase PAN5 Neighboring gene Ssz1p Neighboring gene rRNA-binding ribosome biosynthesis protein Neighboring gene hydroxyacyl-thioester dehydratase HTD2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 18S rRNA processing requires the RNA helicase-like protein Rrp3. O'Day CL, et al. Nucleic Acids Res, 1996 Aug 15. PMID 8774901, Free PMC Article
    2. The E1E4 protein of human papillomavirus type 16 associates with a putative RNA helicase through sequences in its C terminus. Doorbar J, et al. J Virol, 2000 Nov. PMID 11024137, Free PMC Article
    3. Duplex destabilization by four ribosomal DEAD-box proteins. Garcia I, et al. Biochemistry, 2012 Dec 18. PMID 23153376
    4. Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins. Garcia I, et al. Biochemistry, 2008 Nov 25. PMID 18975973, Free PMC Article
    5. Comprehensive mutational analysis of yeast DEXD/H box RNA helicases required for small ribosomal subunit synthesis. Granneman S, et al. Mol Cell Biol, 2006 Feb. PMID 16449634, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-dependent ATPase RRP3
    NP_011932.2
    • Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      227532..229037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179195.1 → NP_011932.2  TPA: RNA-dependent ATPase RRP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011932.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZSX1, D3DL14, P38712, Q6TQT5, Q6TQT6
      UniProtKB/TrEMBL
      B3LSI4, C7GTW8, N1P4J0
      Conserved Domains (1) summary
      COG0513
      Location:69 → 490
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38712.2

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