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    YAP1801 Yap1801p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YAP1801
    Official Full Name
    Yap1801p
    Primary source
    SGD:S000001204
    Locus tag
    YHR161C
    See related
    AllianceGenome:SGD:S000001204; FungiDB:YHR161C; VEuPathDB:YHR161C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables clathrin binding activity. Involved in endocytosis. Located in plasma membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein) and SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YAP1801 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (420373..422286, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Tda11p Neighboring gene Pex18p Neighboring gene mitochondrial pyruvate carrier Neighboring gene 6-phosphogluconolactonase SOL3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization. Dores MR, et al. Traffic, 2010 Jan. PMID 19903324, Free PMC Article
    2. The Sla2p talin domain plays a role in endocytosis in Saccharomyces cerevisiae. Baggett JJ, et al. Genetics, 2003 Dec. PMID 14704157, Free PMC Article
    3. Interaction between Epsin/Yap180 adaptors and the scaffolds Ede1/Pan1 is required for endocytosis. Maldonado-Báez L, et al. Mol Biol Cell, 2008 Jul. PMID 18448668, Free PMC Article
    4. Subtleties in Clathrin heavy chain binding boxes provide selectivity among adaptor proteins of budding yeast. Defelipe LA, et al. Nat Commun, 2024 Nov 7. PMID 39511183, Free PMC Article
    5. Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P(2) during receptor-mediated endocytosis in yeast. Yamamoto W, et al. J Cell Sci, 2018 Jan 4. PMID 29192062

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
      Title: The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    Yap1801p
    NP_012031.1
    • Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      420373..422286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179292.1 → NP_012031.1  TPA: Yap1801p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLB0, P38856
      UniProtKB/TrEMBL
      C8Z9V8, N1P4T8
      Conserved Domains (1) summary
      pfam07651
      Location:3 → 269
      ANTH; ANTH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38856.1

    Gene LinkOut

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