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    lysP lysine:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946667, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lysP
    Official Full Name
    lysine:H(+) symporter
    Primary source
    ECOCYC:EG11337
    Locus tag
    b2156
    See related
    ASAP:ABE-0007131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cadR; ECK2149
    Summary
    LysP is a negative regulator of cadBA expression in the absence of lysine. [More information is available at EcoGene: EG11337]. LysP is one of two principal systems responsible for the uptake of lysine, the other is the ArgT ABC transporter. [More information is available at EcoCyc: EG11337].
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    Genomic context

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    Sequence:
    NC_000913.3 (2247063..2248532, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase/S-lactoylglutathione hydrolase Neighboring gene iron-catecholate outer membrane transporter CirA Neighboring gene DNA-binding transcriptional regulator YeiE Neighboring gene PF03601 family inner membrane protein YeiH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Topological analysis of the lysine-specific permease of Escherichia coli. Ellis J, et al. Microbiology (Reading), 1995 Aug. PMID 7551055
    2. Escherichia coli regulatory mutation affecting lysine transport and lysine decarboxylase. Popkin PS, et al. J Bacteriol, 1980 Feb. PMID 6767681, Free PMC Article
    3. Increase in the rate of L-pipecolic acid production using lat-expressing Escherichia coli by lysP and yeiE amplification. Fujii T, et al. Biosci Biotechnol Biochem, 2002 Sep. PMID 12400704
    4. Construction of an Escherichia coli strain unable to synthesize putrescine, spermidine, or cadaverine: characterization of two genes controlling lysine decarboxylase. Tabor H, et al. J Bacteriol, 1980 Dec. PMID 7002915, Free PMC Article
    5. Sequence analysis of TnphoA insertion sites in Vibrio cholerae mutants defective in rugose polysaccharide production. Ali A, et al. Infect Immun, 2000 Dec. PMID 11083805, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upon induction, lysine-dependent conformational changes in LysP transduce the lysine signal via a direct conformational coupling to CadC without resolving the interaction completely.
      Title: New insights into the interplay between the lysine transporter LysP and the pH sensor CadC in Escherichia coli.
    2. These results indicate that ArgP is a major regulator of lysP expression but that Lrp modulates lysP transcription under lysine-limiting conditions.
      Title: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli.
    3. The results suggest a model according to which CadC is inactivated by an interaction with LysP at a low external lysine concentration.
      Title: The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Topological analysis of the lysine-specific permease of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-lysine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-lysine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to amino acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2247063..2248532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416661.1 lysine:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416661.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A478LCZ7
      Conserved Domains (1) summary
      PRK10836
      Location:1 → 489
      PRK10836; lysine transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version

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