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    mscM miniconductance mechanosensitive channel MscM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948676, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mscM
    Official Full Name
    miniconductance mechanosensitive channel MscM
    Primary source
    ECOCYC:G7840
    Locus tag
    b4159
    See related
    ASAP:ABE-0013621
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4155; yjeP
    Summary
    mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs. [More information is available at EcoGene: EG12478]. YjeP is a member of the small mechanositive ion channel (MscS) family . [More information is available at EcoCyc: G7840].
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    Genomic context

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    Sequence:
    NC_000913.3 (4386047..4389370, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YjeM Neighboring gene uncharacterized protein YjeN Neighboring gene DUF2645 domain-containing inner membrane protein YjeO Neighboring gene phosphatidylserine decarboxylase proenzyme Neighboring gene ribosome small subunit-dependent GTPase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple mechanosensitive ion channels from Escherichia coli, activated at different thresholds of applied pressure. Berrier C, et al. J Membr Biol, 1996 May. PMID 8661505
    2. Structural characterization of Escherichia coli phosphatidylserine decarboxylase. Li QX, et al. J Biol Chem, 1988 Aug 15. PMID 3042771
    3. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli. McLaggan D, et al. Mol Microbiol, 2002 Jan. PMID 11985727
    4. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. Levina N, et al. EMBO J, 1999 Apr 1. PMID 10202137, Free PMC Article
    5. Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12. Sabina J, et al. J Bacteriol, 2003 Oct. PMID 14526028, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to osmotic stress EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    miniconductance mechanosensitive channel MscM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4386047..4389370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418583.1 miniconductance mechanosensitive channel MscM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418583.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FSB2
      Conserved Domains (1) summary
      PRK10929
      Location:1 → 1107
      PRK10929; putative mechanosensitive channel protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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