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    pbpG peptidoglycan DD-endopeptidase PbpG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946662, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pbpG
    Official Full Name
    peptidoglycan DD-endopeptidase PbpG
    Primary source
    ECOCYC:EG12015
    Locus tag
    b2134
    See related
    ASAP:ABE-0007050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2127; yohB
    Summary
    PBP8 is an artifactual OmpT-cleaved proteolytic degradation product of PBP7. [More information is available at EcoGene: EG12015]. PBP7 is a DD-endopeptidase and is a member of the family of penicillin-binding proteins. [More information is available at EcoCyc: EG12015].
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    Genomic context

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    Sequence:
    NC_000913.3 (2223938..2224870, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene beta-D-glucoside glucohydrolase, periplasmic Neighboring gene quinone-dependent D-lactate dehydrogenase Neighboring gene putative inner membrane protein Neighboring gene DedA family protein YohD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Osmolability of Escherichia coli and modification of [125I]ampicillin-binding by competence induction for uptake of transforming DNA. Fischer E. Arch Microbiol, 1989. PMID 2692534
    2. Target for bacteriostatic and bactericidal activities of beta-lactam antibiotics against Escherichia coli resides in different penicillin-binding proteins. Satta G, et al. Antimicrob Agents Chemother, 1995 Apr. PMID 7785976, Free PMC Article
    3. Identification and cloning of the gene encoding penicillin-binding protein 7 of Escherichia coli. Henderson TA, et al. J Bacteriol, 1995 Apr. PMID 7721700, Free PMC Article
    4. Specific interaction of penicillin-binding proteins 3 and 7/8 with soluble lytic transglycosylase in Escherichia coli. Romeis T, et al. J Biol Chem, 1994 Aug 26. PMID 8063800
    5. Penicillin-binding protein 7/8 of Escherichia coli is a DD-endopeptidase. Romeis T, et al. Eur J Biochem, 1994 Sep 1. PMID 7925376

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Identification and cloning of the gene encoding penicillin-binding protein 7 of Escherichia coli.
    2. auxiliary role in maintenance of normal rod shape of E coli
      Title: Endopeptidase penicillin-binding proteins 4 and 7 play auxiliary roles in determining uniform morphology of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell wall organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidoglycan DD-endopeptidase PbpG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2223938..2224870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416638.4 peptidoglycan DD-endopeptidase PbpG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416638.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A7FBY3
      Conserved Domains (1) summary
      PRK11669
      Location:3 → 292
      pbpG; D-alanyl-D-alanine endopeptidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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