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    dppA dipeptide ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948062, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dppA
    Official Full Name
    dipeptide ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:EG10248
    Locus tag
    b3544
    See related
    ASAP:ABE-0011576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    alu; dpp; ECK3531; fpp
    Summary
    DppA binds dipeptides and heme, and mediates chemotaxis to dipeptides through the Tap chemoreceptor. [More information is available at EcoGene: EG10248]. DppA is the periplasmic binding component of the dipeptide ABC transporter. [More information is available at EcoCyc: EG10248].
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    Genomic context

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    Sequence:
    NC_000913.3 (3706098..3707705, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dipeptide ABC transporter membrane subunit DppC Neighboring gene dipeptide ABC transporter membrane subunit DppB Neighboring gene tRNA-Pro Neighboring gene phosphoethanolamine transferase EptB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic degradation and transport of endothiopeptides into Escherichia coli K12 mutant strains. Nowak-Jary J, et al. FEMS Microbiol Lett, 2008 Aug. PMID 18557941
    2. The role of the small regulatory RNA GcvB in GcvB/mRNA posttranscriptional regulation of oppA and dppA in Escherichia coli. Pulvermacher SC, et al. FEMS Microbiol Lett, 2008 Apr. PMID 18312576
    3. Role of the Escherichia coli Hfq protein in GcvB regulation of oppA and dppA mRNAs. Pulvermacher SC, et al. Microbiology (Reading), 2009 Jan. PMID 19118352
    4. Protein patterns of gel-entrapped Escherichia coli cells differ from those of free-floating organisms. Perrot F, et al. Electrophoresis, 2000 Feb. PMID 10726772
    5. Direct determination of the properties of peptide transport systems in Escherichia coli, using a fluorescent-labeling procedure. Payne JW, et al. J Bacteriol, 1979 Jan. PMID 368023, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dipeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dipeptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dipeptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dipeptide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dipeptide transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within heme transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in peptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive chemotaxis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptide ABC transporter periplasmic binding protein
    NP_418001.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3706098..3707705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418001.1 dipeptide ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418001.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN5UHY5
      Conserved Domains (1) summary
      cd08493
      Location:30 → 519
      PBP2_DppA_like; The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold
    Nucleotide Protein
    Heading Accession and Version

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