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    rlmE 23S rRNA 2'-O-ribose U2552 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947689, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rlmE
    Official Full Name
    23S rRNA 2'-O-ribose U2552 methyltransferase
    Primary source
    ECOCYC:EG11507
    Locus tag
    b3179
    See related
    ASAP:ABE-0010447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3168; ftsJ; mrsF; rrmJ
    Summary
    RlmE is the methyltransferase responsible for methylation of 23S rRNA at the 2'-O position of the ribose at the universally conserved U2552 nucleotide . [More information is available at EcoCyc: EG11507].
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    Genomic context

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    Sequence:
    NC_000913.3 (3327035..3327664, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoglucosamine mutase Neighboring gene dihydropteroate synthase Neighboring gene ATP-dependent zinc metalloprotease FtsH Neighboring gene ribosome assembly factor YhbY Neighboring gene transcription elongation factor GreA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active site in RrmJ, a heat shock-induced methyltransferase. Hager J, et al. J Biol Chem, 2002 Nov 1. PMID 12181314
    2. Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. Hager J, et al. J Bacteriol, 2004 Oct. PMID 15375145, Free PMC Article
    3. U2552 methylation at the ribosomal A-site is a negative modulator of translational accuracy. Widerak M, et al. Gene, 2005 Feb 28. PMID 15715963
    4. Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain. Hwang J, et al. J Bacteriol, 2010 Apr. PMID 20172997, Free PMC Article
    5. Structure and function of the ftsH gene in Escherichia coli. Ogura T, et al. Res Microbiol, 1991 Feb-Apr. PMID 1925026

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The rrmJ deletion causes a severe growth defect but the growth impairment can be suppressed by overexpression of Der.
      Title: Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (uridine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (uridine-2'-O-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (uridine-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ribosomal large subunit assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    23S rRNA 2'-O-ribose U2552 methyltransferase
    NP_417646.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3327035..3327664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417646.1 23S rRNA 2'-O-ribose U2552 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417646.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A478LCJ5
      Conserved Domains (1) summary
      PRK11188
      Location:1 → 208
      rrmJ; 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE
    Nucleotide Protein
    Heading Accession and Version

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