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    holB DNA polymerase III subunit delta' [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945661, updated on 3-Dec-2024

    Summary

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    Official Symbol
    holB
    Official Full Name
    DNA polymerase III subunit delta'
    Primary source
    ECOCYC:EG11500
    Locus tag
    b1099
    See related
    ASAP:ABE-0003716
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1085
    Summary
    The crystal structure of delta' has been determined. [More information is available at EcoCyc: EG11500].
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    Genomic context

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    Sequence:
    NC_000913.3 (1155762..1156766)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aminodeoxychorismate lyase Neighboring gene endolytic murein transglycosylase Neighboring gene Tmk Neighboring gene putative metal-dependent hydrolase YcfH Neighboring gene glucose-specific PTS enzyme IIBC component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel assembly mechanism for the DNA polymerase III holoenzyme DnaX complex: association of deltadelta' with DnaX(4) forms DnaX(3)deltadelta'. Pritchard AE, et al. EMBO J, 2000 Dec 1. PMID 11101526, Free PMC Article
    2. The delta and delta ' subunits of the DNA polymerase III holoenzyme are essential for initiation complex formation and processive elongation. Song MS, et al. J Biol Chem, 2001 Sep 14. PMID 11432857
    3. Carboxyl-terminal domain III of the delta' subunit of the DNA polymerase III holoenzyme binds delta. Song MS, et al. J Biol Chem, 2001 Nov 2. PMID 11518714
    4. A three-domain structure for the delta subunit of the DNA polymerase III holoenzyme delta domain III binds delta' and assembles into the DnaX complex. Bullard JM, et al. J Biol Chem, 2002 Apr 12. PMID 11809766
    5. A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader. Thompson JA, et al. J Biol Chem, 2009 Nov 13. PMID 19759003, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of DNA polymerase III complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of DNA polymerase III, clamp loader complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of replisome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase III subunit delta'

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1155762..1156766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415617.1 DNA polymerase III subunit delta' [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415617.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A793CBT5
      Conserved Domains (1) summary
      PRK07993
      Location:1 → 334
      PRK07993; DNA polymerase III subunit delta'; Validated
    Nucleotide Protein
    Heading Accession and Version

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