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    cheZ chemotaxis protein CheZ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946392, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cheZ
    Official Full Name
    chemotaxis protein CheZ
    Primary source
    ECOCYC:EG10151
    Locus tag
    b1881
    See related
    ASAP:ABE-0006278
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1882
    Summary
    Polar localization is dependent on CheA-short. [More information is available at EcoGene: EG10151]. CheZ is a cytosolic phosphatase which functions in the chemotaxis signal transduction complex. [More information is available at EcoCyc: EG10151].
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    Genomic context

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    Sequence:
    NC_000913.3 (1966393..1967037, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene flagellar protein FlhE Neighboring gene flagellar biosynthesis protein FlhA Neighboring gene flagellar biosynthesis protein FlhB Neighboring gene chemotaxis protein CheY Neighboring gene protein-glutamate methylesterase/protein glutamine deamidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Escherichia coli Remodels the Chemotaxis Pathway for Swarming. Partridge JD, et al. mBio, 2019 Mar 19. PMID 30890609, Free PMC Article
    2. Blue Light-Directed Cell Migration, Aggregation, and Patterning. Zhang J, et al. J Mol Biol, 2020 May 1. PMID 32247761
    3. Guiding bacteria with small molecules and RNA. Topp S, et al. J Am Chem Soc, 2007 May 30. PMID 17480075, Free PMC Article
    4. Isolation and characterization of nonchemotactic CheZ mutants of Escherichia coli. Boesch KC, et al. J Bacteriol, 2000 Jun. PMID 10852888, Free PMC Article
    5. Coexpression of the long and short forms of CheA, the chemotaxis histidine kinase, by members of the family Enterobacteriaceae. McNamara BP, et al. J Bacteriol, 1997 Mar. PMID 9045846, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blue Light-Directed Cell Migration, Aggregation, and Patterning.
      Title: Blue Light-Directed Cell Migration, Aggregation, and Patterning.
    2. The suitability for FRET analysis as well as functionality of fusions with SNAP- and HaloTag could be demonstrated by studying the transient interaction between chemotaxis response regulator CheY and its phosphatase CheZ
      Title: A gateway-based system for fast evaluation of protein-protein interactions in bacteria.
    3. Amino acid substitutions distant from the active site can affect CheZ catalytic activity and CheYp binding, perhaps via the propagation of structural or dynamic perturbations through a helical bundle.
      Title: Action at a distance: amino acid substitutions that affect binding of the phosphorylated CheY response regulator and catalysis of dephosphorylation can be far from the CheZ phosphatase active site.
    4. Specific CheA-short (CheA(S)) residues, L123 and L126, were identified as critical for CheZ binding.
      Title: The CheZ binding interface of CheAS is located in alpha-helix E.
    5. simulations suggest that dynamic CheZ localization will sharpen cellular responses to chemoeffectors, increase the range of detectable ligand concentrations, and make adaptation more precise and robust
      Title: Changing cellular location of CheZ predicted by molecular simulations.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bacterial-type flagellum-dependent swarming motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of bacterial-type flagellum-dependent cell motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chemotaxis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bacterial-type flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of methyl accepting chemotaxis protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemotaxis protein CheZ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1966393..1967037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416395.1 chemotaxis protein CheZ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416395.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6PEF1
      Conserved Domains (1) summary
      PRK11166
      Location:1 → 214
      PRK11166; chemotaxis regulator CheZ; Provisional
    Nucleotide Protein
    Heading Accession and Version

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