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    prlC oligopeptidase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948016, updated on 3-Dec-2024

    Summary

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    Official Symbol
    prlC
    Official Full Name
    oligopeptidase A
    Primary source
    ECOCYC:EG11441
    Locus tag
    b3498
    See related
    ASAP:ABE-0011421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3483; opdA
    Summary
    Oligopeptidase A is a cytoplasmic protease with broad specificity. [More information is available at EcoCyc: EG11441].
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    Genomic context

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    Sequence:
    NC_000913.3 (3643140..3645182, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dipeptide/tripeptide:H(+) symporter DtpB Neighboring gene 16S rRNA m(2)G1516 methyltransferase Neighboring gene 23S rRNA m(6)A2030 methyltransferase Neighboring gene glutathione reductase (NADPH)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic characterization of the Escherichia coli oligopeptidase A (OpdA) and the role of the Tyr(607) residue. Lorenzon RZ, et al. Arch Biochem Biophys, 2010 Aug 15. PMID 20513640
    2. Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene. Conlin CA, et al. J Bacteriol, 1992 Sep. PMID 1325967, Free PMC Article
    3. Purification and characterization of proteinase In, a trypsin-like proteinase, in Escherichia coli. Kato M, et al. Eur J Biochem, 1992 Dec 15. PMID 1336454
    4. PrlC, a suppressor of signal sequence mutations in Escherichia coli, can direct the insertion of the signal sequence into the membrane. Trun NJ, et al. J Mol Biol, 1989 Feb 20. PMID 2538634
    5. Characterization and in vivo cloning of prlC, a suppressor of signal sequence mutations in Escherichia coli K12. Trun NJ, et al. Genetics, 1987 Aug. PMID 2957272, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinetic parameters showed the importance of Tyr(607) in OpdA activity as its substitution promoted a decrease in the k(cat)/K(m) value of about 100-fold with Y607F mutant and 1000-fold with Y607A. Both mutations, however, did not affect protein folding.
      Title: Kinetic characterization of the Escherichia coli oligopeptidase A (OpdA) and the role of the Tyr(607) residue.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Escherichia coli prlC gene encodes a trypsin-like proteinase regulating the cell cycle.
    3. OpdA efficiently cleaves the peptides generated by the activity of the three primary ATP-dependent proteases from E. coli-Lon, HslUV, and ClpAP
      Title: Support for a potential role of E. coli oligopeptidase A in protein degradation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal peptide processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oligopeptidase A
    NP_417955.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3643140..3645182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417955.1 oligopeptidase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417955.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N2Z836
      Conserved Domains (1) summary
      PRK10911
      Location:1 → 680
      PRK10911; oligopeptidase A; Provisional
    Nucleotide Protein
    Heading Accession and Version

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