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    rplY 50S ribosomal subunit protein L25 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945618, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rplY
    Official Full Name
    50S ribosomal subunit protein L25
    Primary source
    ECOCYC:EG10885
    Locus tag
    b2185
    See related
    ASAP:ABE-0007231
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2179
    Summary
    rplY is a non-essential gene as judged by the ability to recombineer haploid deletions (Baba, 2006; Korepanov, 2006). [More information is available at EcoGene: EG10885]. The L25 protein is a component of the 50S subunit of the ribosome and binds to 5S rRNA. [More information is available at EcoCyc: EG10885].
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    Genomic context

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    Sequence:
    NC_000913.3 (2282517..2282801)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA pseudouridine(516) synthase Neighboring gene putative DNA repair helicase RadD Neighboring gene nucleoid-associated protein YejK Neighboring gene DUF1414 domain-containing protein YejL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The primary structure of the 5 S RNA binding protein L25 from Escherichia coli ribosomes. Dovgas NV, et al. FEBS Lett, 1975 May 15. PMID 1093874
    2. Long-residency hydration, cation binding, and dynamics of loop E/helix IV rRNA-L25 protein complex. Réblová K, et al. Biophys J, 2004 Nov. PMID 15339800, Free PMC Article
    3. Assignment of resonances of exchangeable protons in the NMR spectrum of the complex formed by Escherichia coli ribosomal protein L25 and uniformly nitrogen-15 enriched 5 S RNA fragment. Kime MJ. FEBS Lett, 1984 Oct 1. PMID 6383867
    4. Crystallization of a ribonuclease-resistant fragment of Escherichia coli 5 S ribosomal RNA and its complex with protein L25. Abdel-Meguid SS, et al. J Mol Biol, 1983 Dec 5. PMID 6197527
    5. [Structural behavior of RNA-binding proteins in free and complex states: ribosomal protein L25 and 5S RNA from Escherichia coli]. Chigradze IuN. Mol Biol (Mosk), 2008 Jul-Aug. PMID 18856069

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The contact with protein L25 is important for the retention of protein L16 within the Escherichia coli ribosome in vivo.
      Title: Role of Protein L25 and Its Contact with Protein L16 in Maintaining the Active State of Escherichia coli Ribosomes in vivo.
    2. The rplY expression regulation represents one more example of regulatory pathways that control ribosome biogenesis in Escherichia coli and related bacteria.
      Title: Regulation of the rplY gene encoding 5S rRNA binding protein L25 in Escherichia coli and related bacteria.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Small genes/gene-products in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5S rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5S rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    50S ribosomal subunit protein L25

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2282517..2282801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416690.1 50S ribosomal subunit protein L25 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416690.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAD2S062
      Conserved Domains (1) summary
      PRK05943
      Location:1 → 94
      PRK05943; 50S ribosomal protein L25; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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