U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    aroG 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945605, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    aroG
    Official Full Name
    3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive
    Primary source
    ECOCYC:EG10079
    Locus tag
    b0754
    See related
    ASAP:ABE-0002560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0743
    Summary
    Expression of aroF and aroG is repressed by the tyrR protein with tyrosine or phenylalanine plus tryptophan, respectively as corepressors The three genes (aroF, aroG and aroH) are widely separated on the coli chromosome. [More information is available at EcoCyc: EG10079].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (785633..786685)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nicotinamide riboside transporter Neighboring gene Zn(2(+))/Cd(2(+))/Ni(2(+))/Cu(2(+)) exporter Neighboring gene PF13985 family protein YbgS Neighboring gene 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Neighboring gene galactose-1-epimerase Neighboring gene galactokinase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Probing the stereochemistry of E. coli 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (phenylalanine-sensitive)-catalyzed synthesis of KDO 8-P analogues. Sundaram AK, et al. J Org Chem, 2000 Sep 22. PMID 10987918
    2. Studies on 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe)from Escherichia coli K12. 2. Kinetic properties. Simpson RJ, et al. Eur J Biochem, 1976 Nov 15. PMID 12952
    3. 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase. Purification and molecular characterization of the phenylalanine-sensitive isoenzyme from Escherichia coli. McCandliss RJ, et al. J Biol Chem, 1978 Jun 25. PMID 26682
    4. Regulation of the Escherichia coli tryptophan operon by early reactions in the aromatic pathway. Held WA, et al. J Bacteriol, 1970 Jan. PMID 4904234, Free PMC Article
    5. Phenylalanine biosynthesis in Escherichia coli K-12: mutants derepressed for chorismate mutase P-prephenate dehydratase. Im SW, et al. J Bacteriol, 1971 Jun. PMID 4934063, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) synthase (DAHP synthase) has a dimer-of-dimers homotetrameric structure, and DAHP oxime bound to only one subunit of each tight dimer.
      Title: Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.
    2. it was demonstrated that the deletion of N-terminus prevents the enzyme from forming a dimeric structure, indicating that the N-terminus of AroG plays a critical role in the formation of the essential tight dimeric structure
      Title: Requirement of the N-terminus for dimer formation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate synthase AroG of Escherichia coli.
    3. the role of metal ion in E. coli DAHP synthase is to position the amino acids with the appropriate geometry required to coordinate and activate the water molecule.
      Title: Insights into the mechanism of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (Phe) from Escherichia coli using a transient kinetic analysis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive
    NP_415275.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      785633..786685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415275.1 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415275.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FP88
      Conserved Domains (1) summary
      PRK09261
      Location:1 → 349
      PRK09261; phospho-2-dehydro-3-deoxyheptonate aldolase; Validated
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.