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    recO recombination mediator protein RecO [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947038, updated on 3-Dec-2024

    Summary

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    Official Symbol
    recO
    Official Full Name
    recombination mediator protein RecO
    Primary source
    ECOCYC:EG10832
    Locus tag
    b2565
    See related
    ASAP:ABE-0008438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2563
    Summary
    In Escherichia coli replication is temporarily inhibited after DNA damage, such as caused by UV, but resumes following a period of time commensurate with the removal of the lesions . [More information is available at EcoCyc: EG10832].
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    Genomic context

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    Sequence:
    NC_000913.3 (2701741..2702469, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene holo-[acyl-carrier-protein] synthase Neighboring gene pyridoxine 5'-phosphate synthase Neighboring gene 30S ribosomal subunit maturation GTPase Era Neighboring gene RNase III Neighboring gene signal peptidase I

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic recombination of bacterial plasmid DNA: effect of RecF pathway mutations on plasmid recombination in Escherichia coli. Kolodner R, et al. J Bacteriol, 1985 Sep. PMID 2993230, Free PMC Article
    2. Homologous pairing of single-stranded DNA and superhelical double-stranded DNA catalyzed by RecO protein from Escherichia coli. Luisi-DeLuca C. J Bacteriol, 1995 Feb. PMID 7836288, Free PMC Article
    3. Purification and characterization of the Escherichia coli RecO protein. Renaturation of complementary single-stranded DNA molecules catalyzed by the RecO protein. Luisi-DeLuca C, et al. J Mol Biol, 1994 Feb 11. PMID 8107098
    4. Escherichia coli RecO protein anneals ssDNA complexed with its cognate ssDNA-binding protein: A common step in genetic recombination. Kantake N, et al. Proc Natl Acad Sci U S A, 2002 Nov 26. PMID 12438681, Free PMC Article
    5. Genetic analysis of the rnc operon of Escherichia coli. Takiff HE, et al. J Bacteriol, 1989 May. PMID 2540151, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
      Title: Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
    2. we used genetics and single-molecule fluorescence microscopy to investigate whether RecF and RecO function together, or separately, in live Escherichia coli cells. We identified conditions in which RecF and RecO functions are genetically separable.
      Title: RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli.
    3. RecOR, and possibly other SSB-interacting proteins, function(s) in part to alter long-range, macroscopic interactions between or throughout nucleoprotein complexes by microscopically altering wrapping and bridging distant sites.
      Title: Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function.
    4. Data show that single-stranded DNA binding proteins (SSB)-interacting proteins RecO, RecG, PriA, and accessory helicase Rep do not correlate with replication at relication forks.
      Title: Are the SSB-Interacting Proteins RecO, RecG, PriA and the DnaB-Interacting Protein Rep Bound to Progressing Replication Forks in Escherichia coli?
    5. The DNA damage-induced DNA compaction was found to be dependent on the recombination proteins RecA, RecO and RecR as well as the SOS-inducible, SMC (structural maintenance of chromosomes)-like protein RecN.
      Title: DNA compaction in the early part of the SOS response is dependent on RecN and RecA.
    6. Data show that UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR at forks blocked in the rep mutant of Escherichia coli.
      Title: UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR in a rep mutant of Escherichia coli.
    7. When an SSB variant that lacks the C-terminal 8 amino acids is used, the capacity of RecOR to facilitate RecA loading onto the ssDNA is largely abolished
      Title: SSB protein limits RecOR binding onto single-stranded DNA.
    8. All three recombination mediator proteins RecFOR are needed to build a functionally competent RecA filament that supports efficient Pol V-mediated translesion synthesis in the presence of ssDNA-binding protein.
      Title: RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis.
    9. genetic analysis of recombination in a recB recD double mutant was performed; results show that conjugational recombination and DNA repair in this mutant are highly dependent on recJ, partially dependent on recFOR, and independent of recQ
      Title: Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in recombinational repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in bacterial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    recombination mediator protein RecO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2701741..2702469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417060.1 recombination mediator protein RecO [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417060.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A3NN10
      Conserved Domains (1) summary
      PRK00085
      Location:1 → 236
      recO; DNA repair protein RecO; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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