U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pyrI aspartate carbamoyltransferase, PyrI subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948763, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pyrI
    Official Full Name
    aspartate carbamoyltransferase, PyrI subunit
    Primary source
    ECOCYC:EG10811
    Locus tag
    b4244
    See related
    ASAP:ABE-0013889
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4239
    Summary
    HT_Cmplx5_Cyt: [More information is available at EcoGene: EG10811]. The regulatory subunit is catalytically inactive but contains the common binding site for the allosteric effectors CTP and ATP . [More information is available at EcoCyc: EG10811].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4470986..4471447, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Mg(2(+)) importing P-type ATPase Neighboring gene enamine/imine deaminase, redox-regulated chaperone Neighboring gene aspartate carbamoyltransferase catalytic subunit Neighboring gene pyrBI operon leader peptide

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutation of gene encoding regulatory polypeptide of aspartate carbamoyltransferase. Feller A, et al. Nature, 1981 Jul 23. PMID 7019721
    2. The N-terminus of the regulatory chain of Escherichia coli aspartate transcarbamoylase is important for both nucleotide binding and heterotropic effects. Sakash JB, et al. Biochemistry, 1998 Jan 6. PMID 9425049
    3. The influence of the regulatory chain amino acids Glu-62 and IIe-12 on the heterotropic properties of Escherichia coli aspartate transcarbamoylase. Dutta M, et al. Biochemistry, 1998 Jun 16. PMID 9628727
    4. Role of allosteric: zinc interdomain region of the regulatory subunit in the allosteric regulation of aspartate transcarbamoylase from Escherichia coli. Rastogi VK, et al. Arch Biochem Biophys, 1998 Jun 15. PMID 9637729
    5. A single mutation in the regulatory chain of Escherichia coli aspartate transcarbamoylase results in an extreme T-state structure. Williams MK, et al. J Mol Biol, 1998 Aug 7. PMID 9680480

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    2. studies of the transition between the R and T states involving the quaternary structure of the protein; results emphasize a significant role of the protein-solvent interactions
      Title: Cooperativity and high pressure: stabilization of the R conformation of the allosteric aspartate transcarbamylase under the influence of pressure.
    3. mutant Q137A enzyme was studied by time-resolved, small-angle X-ray scattering and its structure was determined in the presence of N-phosphonacetyl-L-aspartate to 2.7 angstroms resolution
      Title: A single amino acid substitution in the active site of Escherichia coli aspartate transcarbamoylase prevents the allosteric transition.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aspartate carbamoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aspartate carbamoyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of aspartate carbamoyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    aspartate carbamoyltransferase, PyrI subunit
    NP_418665.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4470986..4471447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418665.1 aspartate carbamoyltransferase, PyrI subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418665.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0G282
      Conserved Domains (1) summary
      TIGR00240
      Location:4 → 153
      ATCase_reg; aspartate carbamoyltransferase, regulatory subunit
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.