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    accA acetyl-CoA carboxyltransferase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944895, updated on 3-Dec-2024

    Summary

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    Official Symbol
    accA
    Official Full Name
    acetyl-CoA carboxyltransferase subunit alpha
    Primary source
    ECOCYC:EG11647
    Locus tag
    b0185
    See related
    ASAP:ABE-0000630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0184
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    Genomic context

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    Sequence:
    NC_000913.3 (208621..209580)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid A disaccharide synthase Neighboring gene RNase HII Neighboring gene DNA polymerase III subunit alpha Neighboring gene lysine decarboxylase 2 Neighboring gene VOC domain-containing protein YaeR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acetyl CoA carboxylase, II. Deomonstration of biotin-protein and biotin carboxylase subunits. Alberts AW, et al. Proc Natl Acad Sci U S A, 1969 Aug. PMID 4901473, Free PMC Article
    2. A bisubstrate analog inhibitor of the carboxyltransferase component of acetyl-CoA carboxylase. Levert KL, et al. Biochem Biophys Res Commun, 2002 Mar 15. PMID 11883946
    3. Overexpression and kinetic characterization of the carboxyltransferase component of acetyl-CoA carboxylase. Blanchard CZ, et al. J Biol Chem, 1998 Jul 24. PMID 9668099
    4. Acetyl CoA carboxylase. I. Requirement for two protein fractions. Alberts AW, et al. Proc Natl Acad Sci U S A, 1968 Feb. PMID 4868901, Free PMC Article
    5. The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Bilder P, et al. Biochemistry, 2006 Feb 14. PMID 16460018

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxyl- or carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within long-chain fatty acid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of acetate CoA-transferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of acetyl-CoA carboxylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of acetyl-CoA carboxylase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acetyl-CoA carboxyltransferase subunit alpha
    NP_414727.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      208621..209580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414727.1 acetyl-CoA carboxyltransferase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414727.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN5UG88
      Conserved Domains (1) summary
      PRK05724
      Location:1 → 318
      PRK05724; acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated
    Nucleotide Protein
    Heading Accession and Version

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