U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sdaB L-serine deaminase II [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947262, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sdaB
    Official Full Name
    L-serine deaminase II
    Primary source
    ECOCYC:EG11623
    Locus tag
    b2797
    See related
    ASAP:ABE-0009172
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2792
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11623]. L-serine deaminase II (SdaB) is one of three enzymes carrying out the sole step in the pathway of L-serine degradation, converting serine into a basic cellular building block, pyruvate. [More information is available at EcoCyc: EG11623].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2929576..2930943)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleotide 5'-monophosphate nucleosidase Neighboring gene L-serine:H(+) symporter SdaC Neighboring gene flap endonuclease Neighboring gene L-1,2-propanediol oxidoreductase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli. Wiebe MA, et al. mBio, 2022 Dec 20. PMID 36468870, Free PMC Article
    2. Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12. Zhang X, et al. Mol Microbiol, 2008 Aug. PMID 18532981
    3. Sequencing and characterization of the sdaB gene from Escherichia coli K-12. Shao Z, et al. Eur J Biochem, 1993 Mar 15. PMID 8385012
    4. Amino acid stabilization for cell-free protein synthesis by modification of the Escherichia coli genome. Michel-Reydellet N, et al. Metab Eng, 2004 Jul. PMID 15256209
    5. Sequencing and characterization of the sdaC gene and identification of the sdaCB operon in Escherichia coli K12. Shao Z, et al. Eur J Biochem, 1994 Jun 15. PMID 8026499

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
      Title: Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-serine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    L-serine deaminase II
    NP_417277.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2929576..2930943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417277.1 L-serine deaminase II [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417277.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9APC2, A0A7A7B606
      Conserved Domains (1) summary
      TIGR00720
      Location:2 → 451
      sda_mono; L-serine dehydratase, iron-sulfur-dependent, single chain form
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.