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    argG argininosuccinate synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947590, updated on 3-Dec-2024

    Summary

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    Official Symbol
    argG
    Official Full Name
    argininosuccinate synthetase
    Primary source
    ECOCYC:EG10068
    Locus tag
    b3172
    See related
    ASAP:ABE-0010428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3161
    Summary
    The subunit structure is not known. [More information is available at EcoCyc: EG10068].
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    Genomic context

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    Sequence:
    NC_000913.3 (3318637..3319980)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribosome maturation factor RimP Neighboring gene tRNA-Met Neighboring gene putative hydrolase YhbX Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequences of the genes encoding argininosuccinate synthetase in Escherichia coli and Saccharomyces cerevisiae: comparison with methanogenic archaebacteria and mammals. Van Vliet F, et al. Gene, 1990 Oct 30. PMID 2123815
    2. Complementation of argG and hisA mutations of Escherichia coli by DNA cloned from the archaebacterium Methanococcus voltae. Wood AG, et al. J Bacteriol, 1983 Oct. PMID 6352676, Free PMC Article
    3. Recognition of overlapping nucleotides by AraC and the sigma subunit of RNA polymerase. Dhiman A, et al. J Bacteriol, 2000 Sep. PMID 10960090, Free PMC Article
    4. Transcription regulation coupling of the divergent argG and metY promoters in Escherichia coli K-12. Krin E, et al. J Bacteriol, 2003 May. PMID 12730174, Free PMC Article
    5. Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression. Charlier D, et al. J Mol Biol, 1992 Jul 20. PMID 1640456

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables argininosuccinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables argininosuccinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables argininosuccinate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in argininosuccinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urea cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    argininosuccinate synthetase
    NP_417640.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3318637..3319980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417640.1 argininosuccinate synthetase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417640.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376CZC6, A0A376JTA2, A0A785EPM8
      Conserved Domains (1) summary
      PRK05370
      Location:1 → 446
      PRK05370; argininosuccinate synthase; Validated
    Nucleotide Protein
    Heading Accession and Version

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