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    pepB aminopeptidase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948766, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pepB
    Official Full Name
    aminopeptidase B
    Primary source
    ECOCYC:EG12310
    Locus tag
    b2523
    See related
    ASAP:ABE-0008305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2520; yfhI
    Summary
    Aminopeptidase B (PepB) is one of four cysteinylglycinases in Escherichia coli. [More information is available at EcoCyc: EG12310].
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    Genomic context

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    Sequence:
    NC_000913.3 (2655075..2656358, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative toxic protein TimP Neighboring gene protein SseB Neighboring gene accessory iron-sulfur cluster assembly protein IscX Neighboring gene reduced ferredoxin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two M17 family members in Escherichia coli, Peptidase A and Peptidase B. Bhosale M, et al. Biochem Biophys Res Commun, 2010 Apr 23. PMID 20350528
    2. Purification and characterization of aminopeptidase B from Escherichia coli K-12. Suzuki H, et al. Biosci Biotechnol Biochem, 2001 Jul. PMID 11515538
    3. Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis. Minasov G, et al. Protein Sci, 2020 Jul. PMID 32306515, Free PMC Article
    4. Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C. Kazakov T, et al. J Bacteriol, 2008 Apr. PMID 18223070, Free PMC Article
    5. Soluble di- and aminopeptidases in Escherichia K-12. Dispensible enzymes. Hermsdorf CL, et al. Int J Pept Protein Res, 1979 Feb. PMID 372108

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis.
      Title: Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis.
    2. Data show that PepB can effectively process heptapeptide-nucleotide microcin C (McC).
      Title: Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptide catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminopeptidase B
    NP_417018.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2655075..2656358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417018.4 aminopeptidase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417018.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TWH6
      Conserved Domains (1) summary
      PRK05015
      Location:5 → 427
      PRK05015; aminopeptidase B; Provisional
    Nucleotide Protein
    Heading Accession and Version

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