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    ydfG 3-hydroxy acid dehydrogenase YdfG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946085, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ydfG
    Official Full Name
    3-hydroxy acid dehydrogenase YdfG
    Primary source
    ECOCYC:EG12345
    Locus tag
    b1539
    See related
    ASAP:ABE-0005137
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1532
    Summary
    The product of the oxidation of the 3-hydroxyl group of L-allo-threonine is aminoacetone, via spontaneous decarboxylation of the primary reaction product L-2-amino-3-ketobutyrate. [More information is available at EcoGene: EG12345]. The ydfG gene encodes a homotetrameric NADP(+)-dependent 3-hydroxy acid dehydrogenase . [More information is available at EcoCyc: EG12345].
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    Genomic context

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    Sequence:
    NC_000913.3 (1627517..1628263)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF02464 family protein YdeJ Neighboring gene peptidyl-dipeptidase Dcp Neighboring gene DNA-binding transcriptional repressor RspR Neighboring gene putative selenoprotein YdfZ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C). Fujisawa H, et al. Biochim Biophys Acta, 2003 Jan 31. PMID 12535615
    2. dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product. Henrich B, et al. J Bacteriol, 1993 Nov. PMID 8226676, Free PMC Article
    3. Proteomic analysis of beryllium-induced genotoxicity in an Escherichia coli mutant model system. Taylor-McCabe KJ, et al. Proteomics, 2006 Mar. PMID 16447159
    4. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. Kim KS, et al. J Bacteriol, 2010 Aug. PMID 20400551, Free PMC Article
    5. Intrinsic and extrinsic approaches for detecting genes in a bacterial genome. Borodovsky M, et al. Nucleic Acids Res, 1994 Nov 11. PMID 7984428, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyrate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxypropionate dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxypropionate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine 3-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uracil catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within uracil catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-hydroxy acid dehydrogenase YdfG
    NP_416057.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1627517..1628263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416057.1 3-hydroxy acid dehydrogenase YdfG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416057.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R1P1, A0A8S7TGA8
      Conserved Domains (1) summary
      PRK10538
      Location:1 → 248
      PRK10538; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG
    Nucleotide Protein
    Heading Accession and Version

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