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    grxA reduced glutaredoxin 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945479, updated on 3-Dec-2024

    Summary

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    Official Symbol
    grxA
    Official Full Name
    reduced glutaredoxin 1
    Primary source
    ECOCYC:EG10417
    Locus tag
    b0849
    See related
    ASAP:ABE-0002893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0840; grx
    Summary
    Glutaredoxins are ubiquitous proteins that catalyze the reduction of disulfides via reduced glutathione (GSH). [More information is available at EcoCyc: EG10417].
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    Genomic context

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    Sequence:
    NC_000913.3 (890496..890753, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YbjL Neighboring gene putative inner membrane protein Neighboring gene DUF1418 domain-containing protein YbjC Neighboring gene NADPH-dependent nitro/quinone reductase NfsA Neighboring gene ribosomal protein S6 modification protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR structure of oxidized Escherichia coli glutaredoxin: comparison with reduced E. coli glutaredoxin and functionally related proteins. Xia TH, et al. Protein Sci, 1992 Mar. PMID 1304339, Free PMC Article
    2. Anti-oxidative stress system in cyanobacteria. Significance of type II peroxiredoxin and the role of 1-Cys peroxiredoxin in Synechocystis sp. strain PCC 6803. Hosoya-Matsuda N, et al. J Biol Chem, 2005 Jan 7. PMID 15509585
    3. oxyR-dependent induction of Escherichia coli grx gene expression by peroxide stress. Tao K. J Bacteriol, 1997 Sep. PMID 9294462, Free PMC Article
    4. Comparison of backbone dynamics of reduced and oxidized Escherichia coli glutaredoxin-1 using 15N NMR relaxation measurements. Kelley JJ 3rd, et al. Biochemistry, 1997 Apr 22. PMID 9125525
    5. Insights into deglutathionylation reactions. Different intermediates in the glutaredoxin and protein disulfide isomerase catalyzed reactions are defined by the gamma-linkage present in glutathione. Peltoniemi MJ, et al. J Biol Chem, 2006 Nov 3. PMID 16956877

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. grxA plays a role in E. coli resistance to distant UV irradiation and in regulation of SOS response.
      Title: [The role of thiol redox systems in response of Escherichia coli to distant UV irradiation].
    2. N-terminus verified by Edman degradation on complete protein
      Title: The primary structure of Escherichia coli glutaredoxin. Distant homology with thioredoxins in a superfamily of small proteins with a redox-active cystine disulfide/cysteine dithiol.
    3. in contrast to the glutaredoxin-glutathione mixed disulfide intermediate, the only intermediate in the protein disulfide isomerases (PDI)-catalyzed reaction was PDI peptide mixed disulfide
      Title: Insights into deglutathionylation reactions. Different intermediates in the glutaredoxin and protein disulfide isomerase catalyzed reactions are defined by the gamma-linkage present in glutathione.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase (glutathione) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cysteine biosynthetic process via S-sulfo-L-cysteine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cysteine biosynthetic process via S-sulfo-L-cysteine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deoxyribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfate assimilation via adenylyl sulfate reduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfate assimilation via adenylyl sulfate reduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    reduced glutaredoxin 1
    NP_415370.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      890496..890753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415370.1 reduced glutaredoxin 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415370.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QUD5, A0A8T6BIS5
      Conserved Domains (1) summary
      PRK11200
      Location:1 → 84
      grxA; glutaredoxin 1; Provisional
    Nucleotide Protein
    Heading Accession and Version

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