tadA tRNA adenosine(34) deaminase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: tadA
Official Full Name: tRNA adenosine(34) deaminase
Primary source: ECOCYC:EG11372
Locus tag: b2559
See related: ASAP:ABE-0008419
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2557; yfhC
Summary: Previously reported non-essential nature was mistakenly based on an insertion that removed the last 17 aa, but the truncated enzyme is active. [More information is available at EcoGene: EG11372]. TadA is a tRNA-specific adenosine deaminase that belongs to the family of adenosine deaminases of tRNA (ADATs). [More information is available at EcoCyc: EG11372].
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NC_000913.3 Genomic Context describing neighboring genes

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High-efficiency and multiplex adenine base editing in plants using new TadA variants.
Title: High-efficiency and multiplex adenine base editing in plants using new TadA variants.
This work begins to define the chemical and structural determinants responsible for catalysis and substrate recognition and lays the foundation for detailed mechanistic analysis of this essential enzyme.
Title: Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase.
structural study of prokaryotic tadA
Title: Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA-specific adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine-34 deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-specific adenosine-34 deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA-specific adenosine-34 deaminase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenosine to inosine editing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA wobble adenosine to inosine editing	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA wobble adenosine to inosine editing	IEA Inferred from Electronic Annotation more info