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    nrdR NrdR transcriptional repressor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947437, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nrdR
    Official Full Name
    NrdR transcriptional repressor
    Primary source
    ECOCYC:EG11320
    Locus tag
    b0413
    See related
    ASAP:ABE-0001437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0407; ybaD
    Summary
    NrdR has been shown to regulate all three Nrd systems and to bind to the predicted NrdR binding sites (Torrents, 2007). [More information is available at EcoGene: EG11320]. NrdR is a zinc finger/ATP cone transcriptional regulatory protein that regulates the expression of several operons encoding ribonucleotide reductases. [More information is available at EcoCyc: EG11320].
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    Genomic context

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    Sequence:
    NC_000913.3 (433002..433451)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleoside-specific channel-forming protein Tsx Neighboring gene putative lipoprotein YajI Neighboring gene fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase Neighboring gene 6,7-dimethyl-8-ribityllumazine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection. Dreux N, et al. Infect Immun, 2015 Apr. PMID 25605769, Free PMC Article
    2. NrdR Transcription Regulation: Global Proteome Analysis and Its Role in Escherichia coli Viability and Virulence. Naveen V, et al. PLoS One, 2016. PMID 27275780, Free PMC Article
    3. Cooperative and allosterically controlled nucleotide binding regulates the DNA binding activity of NrdR. McKethan BL, et al. Mol Microbiol, 2013 Oct. PMID 23941567
    4. Regulation of the operon encoding ribonucleotide reductase in Escherichia coli: evidence for both positive and negative control. Tuggle CK, et al. EMBO J, 1986 May. PMID 3013616, Free PMC Article
    5. Regulation of the operon encoding ribonucleotide reductase: role of the negative sites in nrd repression. Tuggle CK, et al. J Bacteriol, 1990 Apr. PMID 2180902, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that elevated expression of NrdR could be a suitable means to retard bacterial growth and virulence, as its elevated expression reduces bacterial fitness and impairs host cell adhesion.
      Title: NrdR Transcription Regulation: Global Proteome Analysis and Its Role in Escherichia coli Viability and Virulence.
    2. Knockout of nrdR gene decreased adherent-invasive Escherichia coli's ability to colonize the gut mucosa of transgenic mice that express human CEACAM6
      Title: Ribonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection.
    3. A model is proposed in which NrdR selectively binds (deoxy)nucleoside triphosphates, which are hydrolysed to their monophosphate counterparts in order to regulate DNA binding.
      Title: Cooperative and allosterically controlled nucleotide binding regulates the DNA binding activity of NrdR.
    4. Results show that the NrdR/YbaD protein differentially regulates the expression of the three sets of ribonucleotide reductase genes.
      Title: NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NrdR transcriptional repressor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      433002..433451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414947.1 NrdR transcriptional repressor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414947.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0A8D0
      Conserved Domains (1) summary
      PRK00464
      Location:1 → 147
      nrdR; transcriptional repressor NrdR
    Nucleotide Protein
    Heading Accession and Version

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