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    pdeR cyclic di-GMP phosphodiesterase PdeR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945868, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pdeR
    Official Full Name
    cyclic di-GMP phosphodiesterase PdeR
    Primary source
    ECOCYC:G6639
    Locus tag
    b1285
    See related
    ASAP:ABE-0004317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1280; gmr; yciR
    Summary
    Gmr has an N-terminal PAS domain, a putative diguanylate cyclase GGDEF domain, then a C-terminal cyclic-di-GMP phosphodiesterase EAL domain. [More information is available at EcoGene: EG13415]. Gmr/YciR controls curli biosynthesis by reducing transcription of the regulator CsgD, probably by degradation of the signalling molecule c-di-GMP. [More information is available at EcoCyc: G6639].
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    Genomic context

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    Sequence:
    NC_000913.3 (1344757..1346742, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator YciT Neighboring gene UPF0509 family protein YciZ Neighboring gene protein YmiD Neighboring gene putative protein YmiB Neighboring gene RNase II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNase II levels change according to the growth conditions: characterization of gmr, a new Escherichia coli gene involved in the modulation of RNase II. Cairrão F, et al. Mol Microbiol, 2001 Mar. PMID 11260472
    2. The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control. Lindenberg S, et al. EMBO J, 2013 Jul 17. PMID 23708798, Free PMC Article
    3. Degradation of mRNA in Escherichia coli. Jain C. IUBMB Life, 2002 Dec. PMID 12665241
    4. Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli. Weber H, et al. Mol Microbiol, 2006 Nov. PMID 17010156
    5. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-guanylate-specific phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-guanylate-specific phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic di-GMP phosphodiesterase PdeR
    NP_415801.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1344757..1346742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415801.1 cyclic di-GMP phosphodiesterase PdeR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415801.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CKH6
      Conserved Domains (1) summary
      PRK10060
      Location:1 → 660
      PRK10060; cyclic di-GMP phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version

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