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    folM dihydromonapterin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949096, updated on 3-Dec-2024

    Summary

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    Official Symbol
    folM
    Official Full Name
    dihydromonapterin reductase
    Primary source
    ECOCYC:G6862
    Locus tag
    b1606
    See related
    ASAP:ABE-0005364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1601; ydgB
    Summary
    The folM gene encodes a dihydrofolate reductase. [More information is available at EcoCyc: G6862].
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    Genomic context

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    Sequence:
    NC_000913.3 (1680976..1681698)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1471 domain-containing protein YdgH Neighboring gene putative arginine:ornithine antiporter Neighboring gene GlpM family protein Neighboring gene DNA-binding transcriptional regulator RstA Neighboring gene sensory histidine kinase RstB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigation of osmolyte effects on FolM: comparison with other dihydrofolate reductases. Bhojane PP, et al. Biochemistry, 2014 Mar 4. PMID 24517487
    2. Mass spectrometry on hydrogen/deuterium exchange of dihydrofolate reductase: effects of ligand binding. Yamamoto T, et al. J Biochem, 2004 Jun. PMID 15213241
    3. FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli. Giladi M, et al. J Bacteriol, 2003 Dec. PMID 14617668, Free PMC Article
    4. Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids. Maini R, et al. Biochemistry, 2015 Jun 16. PMID 25982410, Free PMC Article
    5. FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa. Pribat A, et al. J Bacteriol, 2010 Jan. PMID 19897652, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that substrate specificity of peptidyl transferase activity of 23S rRNA allows incorporation of beta-alanine analogs into dihydrofolate reductase (folM) at four sites.
      Title: Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids.
    2. Purified FolM in E. coli showed high, NADPH-dependent dihydromonapterin reductase activity.
      Title: FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dihydrofolate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydrofolate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydromonapterin reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 10-formyltetrahydrofolate biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within folic acid biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pteridine-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydromonapterin reductase
    NP_416123.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1680976..1681698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416123.1 dihydromonapterin reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416123.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EKB0
      Conserved Domains (1) summary
      PRK06483
      Location:5 → 240
      PRK06483; dihydromonapterin reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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