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    mgrB PhoQ kinase inhibitor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946351, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mgrB
    Official Full Name
    PhoQ kinase inhibitor
    Primary source
    ECOCYC:G7002
    Locus tag
    b1826
    See related
    ASAP:ABE-0006078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1824; yobG
    Summary
    Mg(2+) stimulon-PhoPQ regulon. [More information is available at EcoGene: EG14383]. Transcription of mgrB is induced by low magnesium and is controlled by the PhoP/PhoQ two-component system . [More information is available at EcoCyc: G7002].
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    Genomic context

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    Sequence:
    NC_000913.3 (1908623..1908766, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2527 domain-containing protein YobF Neighboring gene uncharacterized protein YebO Neighboring gene uncharacterized protein YobH Neighboring gene DNA-binding transcriptional repressor KdgR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Perturbation of the oxidizing environment of the periplasm stimulates the PhoQ/PhoP system in Escherichia coli. Lippa AM, et al. J Bacteriol, 2012 Mar. PMID 22267510, Free PMC Article
    2. Isolation and molecular characterization of the locked-on mutant of Mg2+ sensor PhoQ in Escherichia coli. Minagawa S, et al. Biosci Biotechnol Biochem, 2005 Jul. PMID 16041131
    3. MgrB affects the acid stress response of Escherichia coli by modulating the expression of iraM. Xu J, et al. FEMS Microbiol Lett, 2019 Jun 1. PMID 31158277
    4. Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli. Minagawa S, et al. J Bacteriol, 2003 Jul. PMID 12813061, Free PMC Article
    5. Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component systems of Escherichia coli. Eguchi Y, et al. J Bacteriol, 2004 May. PMID 15126461, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that MgrB affects the acid resistance of E. coli by modulating the expression of iraM, but not completely through PhoP/Q.
      Title: MgrB affects the acid stress response of Escherichia coli by modulating the expression of iraM.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to magnesium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PhoQ kinase inhibitor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1908623..1908766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416340.1 PhoQ kinase inhibitor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416340.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6G9RWA9
      Conserved Domains (1) summary
      PRK10299
      Location:1 → 47
      PRK10299; PhoP/PhoQ regulator MgrB
    Nucleotide Protein
    Heading Accession and Version

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