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    rcnR DNA-binding transcriptional repressor RcnR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947114, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rcnR
    Official Full Name
    DNA-binding transcriptional repressor RcnR
    Primary source
    ECOCYC:G7137
    Locus tag
    b2105
    See related
    ASAP:ABE-0006964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2098; yohL
    Summary
    The RcnR-rcnA promoter interaction is inhibited by nickel and cobalt; an rcnR mutant constitutively expresses rcnA (Iwig, 2006). rcnR and frmR are paralogs. [More information is available at EcoGene: EG14070]. The RcnR (resistance to cobalt and nickel regulator) protein is an addition to the set of transcriptional metallo-regulator proteins of Escherichia coli (some of the main ones are Fur, CueR, CusR, MntR, Zur, ZntR, and NikR) , regulating the transcriptional expression of a recently described efflux protein, RcnA , to maintain nickel and cobalt homeostasis . [More information is available at EcoCyc: G7137].
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    Genomic context

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    Sequence:
    NC_000913.3 (2185524..2185796, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative glycosyl hydrolase YegX Neighboring gene bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase Neighboring gene hydroxyethylthiazole kinase Neighboring gene Ni(2(+))/Co(2(+)) exporter Neighboring gene periplasmic protein involved in nickel/cobalt export

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mycobacterium tuberculosis NmtR harbors a nickel sensing site with parallels to Escherichia coli RcnR. Reyes-Caballero H, et al. Biochemistry, 2011 Sep 20. PMID 21819125, Free PMC Article
    2. DNA recognition and wrapping by Escherichia coli RcnR. Iwig JS, et al. J Mol Biol, 2009 Oct 23. PMID 19703465
    3. The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis. Koch D, et al. Biometals, 2007 Oct. PMID 17120142
    4. Ni(II) and Co(II) sensing by Escherichia coli RcnR. Iwig JS, et al. J Am Chem Soc, 2008 Jun 18. PMID 18505253, Free PMC Article
    5. Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli. Rodrigue A, et al. J Bacteriol, 2005 Apr. PMID 15805538, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor RcnR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2185524..2185796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416608.1 DNA-binding transcriptional repressor RcnR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416608.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NCR4
      Conserved Domains (1) summary
      PRK15039
      Location:1 → 90
      PRK15039; Ni(II)/Co(II)-binding transcriptional repressor RcnR
    Nucleotide Protein
    Heading Accession and Version

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