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    lhr ATP-dependent helicase Lhr [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946156, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lhr
    Official Full Name
    ATP-dependent helicase Lhr
    Primary source
    ECOCYC:EG11548
    Locus tag
    b1653
    See related
    ASAP:ABE-0005525
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1649; rhlF
    Summary
    Lhr codes for the longest known protein in Escherichia coli. [More information is available at EcoCyc: EG11548].
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    Genomic context

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    Sequence:
    NC_000913.3 (1729087..1733703)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lactoylglutathione lyase Neighboring gene ribonuclease T Neighboring gene glutaredoxin 4 Neighboring gene peptidoglycan endopeptidase/peptidoglycan L,D-carboxypeptidase MepH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules. Warren GM, et al. Nucleic Acids Res, 2021 Apr 19. PMID 33744958, Free PMC Article
    2. Sequence and transcriptional analysis of the Escherichia coli rnt gene encoding RNase T. Huang S, et al. J Biol Chem, 1992 Dec 15. PMID 1460056
    3. Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library. Yao J, et al. Nucleic Acids Res, 2005. PMID 15947133, Free PMC Article
    4. Generating tetracycline-inducible auxotrophy in Escherichia coli and Salmonella enterica serovar Typhimurium by using an insertion element and a hyperactive transposase. Köstner M, et al. Appl Environ Microbiol, 2006 Jul. PMID 16820464, Free PMC Article
    5. The gene for the longest known Escherichia coli protein is a member of helicase superfamily II. Reuven NB, et al. J Bacteriol, 1995 Oct. PMID 7559321, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules.
      Title: Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3'-5' DNA/RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent helicase Lhr
    NP_416170.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1729087..1733703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416170.1 ATP-dependent helicase Lhr [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416170.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NKK1, A0A6M9WQ49
      Conserved Domains (2) summary
      PRK09751
      Location:49 → 1538
      PRK09751; putative ATP-dependent helicase Lhr; Provisional
      cl28899
      Location:27 → 66
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein
    Heading Accession and Version

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