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    kdsB 3-deoxy-manno-octulosonate cytidylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945539, updated on 3-Dec-2024

    Summary

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    Official Symbol
    kdsB
    Official Full Name
    3-deoxy-manno-octulosonate cytidylyltransferase
    Primary source
    ECOCYC:EG10519
    Locus tag
    b0918
    See related
    ASAP:ABE-0003122
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0909
    Summary
    CMP-KDO synthetase activates the 8-carbon sugar KDO for incorporation into lipopolysaccharide. [More information is available at EcoCyc: EG10519].
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    Genomic context

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    Sequence:
    NC_000913.3 (970852..971598)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-binding lipopolysaccharide transport protein Neighboring gene tetraacyldisaccharide 4'-kinase Neighboring gene interstrand DNA crosslink repair glycosylase Neighboring gene PF03966 family protein YcaR Neighboring gene putative phosphotransferase YcbJ Neighboring gene envelope biogenesis factor Neighboring gene tRNA cmo(5)U34 methyltransferase Neighboring gene chromosome partitioning protein MukF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases. Heyes DJ, et al. J Biol Chem, 2009 Dec 18. PMID 19815542, Free PMC Article
    2. An Escherichia coli expression vector for high-level production of heterologous proteins in fusion with CMP-KDO synthetase. Bolling TJ, et al. Biotechniques, 1990 May. PMID 2162683
    3. Molecular cloning of the structural gene coding for CTP:CMP-3-deoxy-manno-octulosonate cytidylyltransferase from Escherichia coli K-12. Goldman RC, et al. J Bacteriol, 1985 Jul. PMID 2989246, Free PMC Article
    4. Determination of the anomeric specificity of the Escherichia coli CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase by 13C NMR spectroscopy. Kohlbrenner WE, et al. J Biol Chem, 1985 Nov 25. PMID 2997221
    5. 31P and 13C NMR studies of oxygen transfer during catalysis by 3-deoxy-D-manno-octulosonate cytidylyltransferase from Escherichia coli. Kohlbrenner WE, et al. J Biol Chem, 1987 Apr 5. PMID 3031027

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Primary structure of CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-deoxy-manno-octulosonate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-deoxy-manno-octulosonate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-deoxy-manno-octulosonate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within keto-3-deoxy-D-manno-octulosonic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-deoxy-manno-octulosonate cytidylyltransferase
    NP_415438.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      970852..971598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415438.1 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415438.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1JGJ5, A0A376X0Q8
      Conserved Domains (1) summary
      PRK05450
      Location:1 → 248
      PRK05450; 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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