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    hipB antitoxin/DNA-binding transcriptional repressor HipB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946065, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hipB
    Official Full Name
    antitoxin/DNA-binding transcriptional repressor HipB
    Primary source
    ECOCYC:EG10442
    Locus tag
    b1508
    See related
    ASAP:ABE-0005024
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1501
    Summary
    HipB is a transcription factor that negatively autoregulates the hipBA toxin-antitoxin operon. [More information is available at EcoCyc: EG10442].
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    Genomic context

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    Sequence:
    NC_000913.3 (1592176..1592442, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene serine/threonine-protein kinase toxin HipA Neighboring gene pseudo Neighboring gene autoinducer-2 kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of YjjJ toxin of Escherichia coli. Maeda Y, et al. FEMS Microbiol Lett, 2017 Jun 15. PMID 28430938
    2. New kinase regulation mechanism found in HipBA: a bacterial persistence switch. Evdokimov A, et al. Acta Crystallogr D Biol Crystallogr, 2009 Aug. PMID 19622872
    3. Bacterial persistence: some new insights into an old phenomenon. Jayaraman R. J Biosci, 2008 Dec. PMID 19179767
    4. Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin system during prolonged cultivation. Kawano H, et al. Biosci Biotechnol Biochem, 2009 Jan. PMID 19129642
    5. A molecular model for persister in E. coli. Lou C, et al. J Theor Biol, 2008 Nov 21. PMID 18721814

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Despite being a homolog of HipA, YjjJ seems to have different cellular target(s) than that of HipA. HipB, the cognate antitoxin of HipA, also acts as an antitoxin for YjjJ.
      Title: Characterization of YjjJ toxin of Escherichia coli.
    2. HipBA toxin-antitoxin (TA) system affects frequency of survival during the long-term stationary phase
      Title: Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin system during prolonged cultivation.
    3. HipA-HipB-DNA structure reveals the HipB-operator binding mechanism; dimeric HipB interacts with 2 HipA molecules to inhibit its kinase activity; these studies suggest mechanisms for HipA-mediated persistence and its neutralization by HipB
      Title: Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
    4. N-terminus verified by Edman degradation on complete protein
      Title: Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-DNA complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of protein-DNA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antitoxin/DNA-binding transcriptional repressor HipB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1592176..1592442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416025.1 antitoxin/DNA-binding transcriptional repressor HipB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416025.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9I1S1
      Conserved Domains (1) summary
      PRK09726
      Location:1 → 88
      PRK09726; type II toxin-antitoxin system antitoxin HipB
    Nucleotide Protein
    Heading Accession and Version

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