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    FET4 Fet4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FET4
    Official Full Name
    Fet4p
    Primary source
    SGD:S000004938
    Locus tag
    YMR319C
    See related
    AllianceGenome:SGD:S000004938; FungiDB:YMR319C; VEuPathDB:YMR319C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables copper ion transmembrane transporter activity and iron ion transmembrane transporter activity. Involved in protein maturation by copper ion transfer and transition metal ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FET4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (912880..914538, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene NADP-dependent alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae. Dix DR, et al. J Biol Chem, 1994 Oct 21. PMID 7929320
    2. Characterization of the FET4 protein of yeast. Evidence for a direct role in the transport of iron. Dix D, et al. J Biol Chem, 1997 May 2. PMID 9115232
    3. A novel iron-regulated metal transporter from plants identified by functional expression in yeast. Eide D, et al. Proc Natl Acad Sci U S A, 1996 May 28. PMID 8643627, Free PMC Article
    4. Metal transporters that contribute copper to metallochaperones in Saccharomyces cerevisiae. Portnoy ME, et al. Mol Genet Genomics, 2001 Jul. PMID 11523804
    5. Two isoforms of a divalent metal transporter (DMT1) in Schistosoma mansoni suggest a surface-associated pathway for iron absorption in schistosomes. Smyth DJ, et al. J Biol Chem, 2006 Jan 27. PMID 16267047, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copper ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by copper ion transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fet4p
    NP_014052.1
    • Low-affinity Fe(II) transporter of the plasma membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      912880..914538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182832.1 → NP_014052.1  TPA: Fet4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0E7, P40988
      UniProtKB/TrEMBL
      A6ZN37, B3LMK8, N1NXV2
      Conserved Domains (2) summary
      COG5478
      Location:207 → 381
      Fet4; Low affinity Fe/Cu permease [Inorganic ion transport and metabolism]
      cl12096
      Location:454 → 519
      Iron_permease; Low affinity iron permease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40988.2

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