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    PUS4 pseudouridine synthase PUS4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PUS4
    Official Full Name
    pseudouridine synthase PUS4
    Primary source
    SGD:S000005236
    Locus tag
    YNL292W
    See related
    AllianceGenome:SGD:S000005236; FungiDB:YNL292W; VEuPathDB:YNL292W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis and tRNA modification. Located in mitochondrion and nucleus. Orthologous to human TRUB1 (TruB pseudouridine synthase family member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PUS4 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (82806..84017)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Rim21p Neighboring gene Rab GTPase-activating protein MSB3 Neighboring gene Mid1p Neighboring gene replication factor C subunit 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil. Samuelsson T. Nucleic Acids Res, 1991 Nov 25. PMID 1956773, Free PMC Article
    2. Transfer RNA pseudouridine synthases in Saccharomyces cerevisiae. Samuelsson T, et al. J Biol Chem, 1990 May 25. PMID 2187870
    3. The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs. Becker HF, et al. Nucleic Acids Res, 1997 Nov 15. PMID 9358157, Free PMC Article
    4. Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast. Grosshans H, et al. J Biol Chem, 2001 Dec 7. PMID 11571299
    5. Pseudouridine and ribothymidine formation in the tRNA-like domain of turnip yellow mosaic virus RNA. Becker HF, et al. Nucleic Acids Res, 1998 Sep 1. PMID 9705510, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables tRNA pseudouridine(55) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pseudouridine synthase PUS4
    NP_014107.1
    • Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      82806..84017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183130.1 → NP_014107.1  TPA: pseudouridine synthase PUS4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q1, P48567
      UniProtKB/TrEMBL
      A6ZSI6, B3LPD0, B5VQC5, C7GS55, C8ZGN0, G2WLH5, N1P4W9
      Conserved Domains (1) summary
      cd02867
      Location:3 → 331
      PseudoU_synth_TruB_4; Pseudouridine synthase homolog 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48567.1

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