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    Ankrd13a ankyrin repeat domain 13a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd13aprovided by RGD
    Official Full Name
    ankyrin repeat domain 13aprovided by RGD
    Primary source
    RGD:1308577
    See related
    EnsemblRapid:ENSRNOG00000001204 AllianceGenome:RGD:1308577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ankrd13
    Summary
    Predicted to enable ubiquitin-modified protein reader activity. Predicted to be involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Predicted to be located in late endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13A (ankyrin repeat domain 13A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 262.8), Thymus (RPKM 228.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd13a in Genome Data Viewer
    Location:
    12q16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47458828..47488959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41798196..41828327, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47558587..47588486, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA26 Neighboring gene similar to human chromosome 12 open reading frame 76 Neighboring gene GIT ArfGAP 2 Neighboring gene uncharacterized LOC102547088 Neighboring gene trichoplein, keratin filament binding

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Tanno H, et al. Mol Biol Cell, 2012 Apr. PMID 22298428, Free PMC Article
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 13A
    Names
    ankyrin repeat domain 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012148.1 → NP_001012148.1  ankyrin repeat domain-containing protein 13A

      See identical proteins and their annotated locations for NP_001012148.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085774
      UniProtKB/TrEMBL
      F7F6M4, Q5U313
      Related
      ENSRNOP00000001595.6, ENSRNOT00000001595.7
      Conserved Domains (4) summary
      cd00204
      Location:4 → 101
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:156 → 469
      GPCR_chapero_1; GPCR-chaperone
      pfam13637
      Location:41 → 90
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:40 → 71
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47458828..47488959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249461.3 → XP_006249523.3  ankyrin repeat domain-containing protein 13A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL63
      Related
      ENSRNOP00000078565.1, ENSRNOT00000105521.2
      Conserved Domains (3) summary
      sd00045
      Location:151 → 182
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:267 → 581
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:124 → 207
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006249462.3 → XP_006249524.1  ankyrin repeat domain-containing protein 13A isoform X2

      UniProtKB/TrEMBL
      F7F6M4
      Conserved Domains (4) summary
      cd00204
      Location:12 → 88
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:143 → 457
      GPCR_chapero_1; GPCR-chaperone
      pfam13637
      Location:28 → 77
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:27 → 58
      ANK; ANK repeat [structural motif]

    3. XM_039089611.2 → XP_038945539.1  ankyrin repeat domain-containing protein 13A isoform X3

      UniProtKB/TrEMBL
      F7F6M4
      Conserved Domains (1) summary
      pfam11904
      Location:68 → 382
      GPCR_chapero_1; GPCR-chaperone

    4. XM_063271544.1 → XP_063127614.1  ankyrin repeat domain-containing protein 13A isoform X3

      UniProtKB/TrEMBL
      F7F6M4
    Nucleotide Protein Strain
    Heading Accession and Version

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