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    IME1 transcription factor IME1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853556, updated on 17-Dec-2024

    Summary

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    Official Symbol
    IME1
    Official Full Name
    transcription factor IME1
    Primary source
    SGD:S000003854
    Locus tag
    YJR094C
    See related
    AllianceGenome:SGD:S000003854; FungiDB:YJR094C; VEuPathDB:YJR094C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including positive regulation of transcription by RNA polymerase II; pseudohyphal growth; and regulation of meiotic nuclear division. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IME1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (604569..605651, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Bud4p Neighboring gene cleavage polyadenylation factor subunit FIP1 Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L43B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Post-transcriptional regulation of IME1 determines initiation of meiosis in Saccharomyces cerevisiae. Sherman A, et al. Mol Gen Genet, 1993 Mar. PMID 8483452
    2. IME1 gene encodes a transcription factor which is required to induce meiosis in Saccharomyces cerevisiae. Mandel S, et al. Dev Genet, 1994. PMID 8205723
    3. A long region upstream of the IME1 gene regulates meiosis in yeast. Granot D, et al. Mol Gen Genet, 1989 Aug. PMID 2674657
    4. Transcription levels of a noncoding RNA orchestrate opposing regulatory and cell fate outcomes in yeast. Moretto F, et al. Cell Rep, 2021 Jan 19. PMID 33472063, Free PMC Article
    5. IME1, a positive regulator gene of meiosis in S. cerevisiae. Kassir Y, et al. Cell, 1988 Mar 25. PMID 3280136

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IME1 expression is regulated by upstream activation signals which reside within the IME1 promoter.
      Title: Multiple MAPK cascades regulate the transcription of IME1, the master transcriptional activator of meiosis in Saccharomyces cerevisiae.
    2. Epistasis analysis suggests that Ime1 and Ime2 act in the same order in pseudohyphal growth as in meiosis.
      Title: Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources.
    3. study shows that natural variation in sporulation efficiency between oak tree & vineyard strains is due to allelic variation between four nucleotide changes in three transcription factors: IME1, RME1 & RSF1
      Title: Genetic interactions between transcription factors cause natural variation in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor IME1
    NP_012627.1
    • Master meiotic regulator active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; regulator of meiotic commitment; phosphorylated by Rim11p; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      604569..605651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181751.1 → NP_012627.1  TPA: transcription factor IME1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR2, P21190
      UniProtKB/TrEMBL
      B8XW29, C7GMB3, E9P9J2, G2WH96, N1P1P3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21190.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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