RCK2 serine/threonine protein kinase RCK2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RCK2
Official Full Name: serine/threonine protein kinase RCK2
Primary source: SGD:S000004238
Locus tag: YLR248W
See related: AllianceGenome:SGD:S000004238; FungiDB:YLR248W; VEuPathDB:YLR248W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CLK1; CMK3
Summary: Enables protein serine/threonine kinase activity. Involved in cellular response to oxidative stress; osmosensory signaling pathway; and regulation of meiotic nuclear division. Located in cytoplasm. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to several human genes including CAMK2D (calcium/calmodulin dependent protein kinase II delta); MYLK2 (myosin light chain kinase 2); and MYLK3 (myosin light chain kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RCK2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (634252..636084)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP2A(Rts1) antagonizes Rck2-mediated hyperosmotic stress signaling in yeast.
Title: PP2A(Rts1) antagonizes Rck2-mediated hyperosmotic stress signaling in yeast.
Data suggest that Rck2 appears to act as a central hub for many Hog1-mediated secondary phosphorylation events.
Title: Identifying protein kinase-specific effectors of the osmostress response in yeast.
Rck2 degradation upon exposure of cells to high levels of zinc is dependent on Pep4
Title: Degradation of Saccharomyces cervisiae Rck2 upon exposure of cells to high levels of zinc is dependent on Pep4.
Array analyses of total and polysome-associated mRNAs revealed major deregulation of the translational machinery in rck2 mutant cells.
Title: Rck2 is required for reprogramming of ribosomes during oxidative stress.
role in oxidative and metal stress resistance for the MAPK-activated protein kinases Rck1 and Rck2
Title: Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3698 (e-PCR)
- UniSTS:474276

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in osmosensory signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osmosensory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osmosensory signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine protein kinase RCK2

NP_013349.1

EC 2.7.11.1

Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

634252..636084

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182135.1 → NP_013349.1 TPA: serine/threonine protein kinase RCK2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013349.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYP6, P38623, Q02532, Q06557

UniProtKB/TrEMBL

A7A1D1, C7GQY8, G2WJ74, N1NZG9

Conserved Domains (1) summary

cd14096
Location:161 → 478

STKc_RCK1-like; Catalytic domain of RCK1-like Serine/Threonine Kinases