MLP1 Mlp1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MLP1
Official Full Name: Mlp1p
Primary source: SGD:S000001803
Locus tag: YKR095W
See related: AllianceGenome:SGD:S000001803; FungiDB:YKR095W; VEuPathDB:YKR095W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MPL1
Summary: Enables promoter-terminator loop anchoring activity and ribonucleoprotein complex binding activity. Involved in several processes, including negative regulation of protein import into nucleus during spindle assembly checkpoint; poly(A)+ mRNA export from nucleus; and protein localization to nucleus. Located in nuclear envelope and nucleoplasm. Part of nuclear pore nuclear basket. Used to study lung cancer. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MLP1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (619805..625432)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mlp1p and Mlp2p are necessary components of the nuclear basket and they embed the nuclear pore complex within a dynamic protein network
Title: The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome.
Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export
Title: Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export.
The N-terminal domain of Nab2 (residues 1-97) mediates interactions with both the C-terminal globular domain of the nuclear pore-associated protein, myosin-like protein 1 (Mlp1), and the mRNA export factor, Gfd1.
Title: Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2.
Mlps link mRNA transcription and export
Title: Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export.
Mlps play important roles in regulating Ulp1 and subsequently affect sumoylation stasis, growth, and DNA repair
Title: Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables mRNA binding	HDA more info	PubMed
enables promoter-terminator loop anchoring activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribonucleoprotein complex binding	IGI Inferred from Genetic Interaction more info	PubMed
enables ribonucleoprotein complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein import into nucleus during spindle assembly checkpoint	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear mRNA surveillance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear mRNA surveillance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to nuclear pore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in telomere tethering at nuclear periphery	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mlp1p

NP_013021.1

Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex (NPC) with the nuclear interior; involved with Tel1p in telomere length control; forms a coiled-coil parallel homodimer; recruitment and docking of Mlp1p filaments onto the NPC Y-complex involves Nup60p; involved along with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

619805..625432

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179885.1 → NP_013021.1 TPA: Mlp1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013021.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXF5, Q02455

UniProtKB/TrEMBL

G2WIC2

Conserved Domains (5) summary

COG1196
Location:214 → 1087

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PTZ00108
Location:1526 → 1838

PTZ00108; DNA topoisomerase 2-like protein; Provisional

TIGR02168
Location:753 → 1496

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam07926
Location:999 → 1125

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

NF033930
Location:1374 → 1673

pneumo_PspA; pneumococcal surface protein A