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    MAM33 Mam33p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAM33
    Official Full Name
    Mam33p
    Primary source
    SGD:S000001332
    Locus tag
    YIL070C
    See related
    AllianceGenome:SGD:S000001332; FungiDB:YIL070C; VEuPathDB:YIL070C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mitochondrial ribosome binding activity. Involved in aerobic respiration and mitochondrial ribosome assembly. Located in mitochondrion. Is active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAM33 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (230272..231072, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Hop1p Neighboring gene Pci8p Neighboring gene ribosomal 40S subunit protein S24B Neighboring gene SNARE-binding exocyst subunit SEC6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mam33p, an oligomeric, acidic protein in the mitochondrial matrix of Saccharomyces cerevisiae is related to the human complement receptor gC1q-R. Seytter T, et al. Yeast, 1998 Mar 15. PMID 9559539
    2. Mam33 promotes cytochrome c oxidase subunit I translation in Saccharomyces cerevisiae mitochondria. Roloff GA, et al. Mol Biol Cell, 2015 Aug 15. PMID 26108620, Free PMC Article
    3. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. Pu YG, et al. J Struct Biol, 2011 Sep. PMID 21600990
    4. p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation. Muta T, et al. J Biol Chem, 1997 Sep 26. PMID 9305894
    5. The mitospecific domain of Mrp7 (bL27) supports mitochondrial translation during fermentation and is required for effective adaptation to respiration. Anderson JM, et al. Mol Biol Cell, 2022 Jan 1. PMID 34731012, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. found that Mam33 does not associate with the mature mitoribosome
      Title: The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome.
    2. Authors report that Mam33 is a third COX1 translational activator in yeast mitochondria.
      Title: Mam33 promotes cytochrome c oxidase subunit I translation in Saccharomyces cerevisiae mitochondria.
    3. The results provided the structural insights into the putative function of Mmf1 during mitochondrial protein synthesis via Mam33, a protein binding to mitochondrial ribosomal proteins.
      Title: Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytosolic ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mam33p
    NP_012194.1
    • Acidic protein of the mitochondrial matrix; binds unassembled large subunit proteins during ribosome assembly; subunit of a complex containing Mrx6p, Pim1p, and Pet20p that may regulate mtDNA replication; related to the human complement receptor gC1q-R

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      230272..231072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179420.1 → NP_012194.1  TPA: Mam33p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012194.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVL4, P40513, Q6Q5P4
      UniProtKB/TrEMBL
      B3LTS2, C7GKK1, C8ZAH6, N1P219
      Conserved Domains (1) summary
      pfam02330
      Location:57 → 259
      MAM33; Mitochondrial glycoprotein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40513.1

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